Publication detail

Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges

KASTELIK-HRYNIEWIECKA, A. JEWULA, P. BAKALORZ, K. KRAMER-MAREK, G. KUŹNIK, N.

Original Title

Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges

Type

journal article in Web of Science

Language

English

Original Abstract

Recently, the demand for hybrid PET/MRI imaging techniques has increased significantly, which has sparked the investigation into new ways to simultaneously track multiple molecular targets and improve the localization and expression of biochemical markers. Multimodal imaging probes have recently emerged as powerful tools for improving the detection sensitivity and accuracy-both important factors in disease diagnosis and treatment; however, only a limited number of bimodal probes have been investigated in preclinical models. Herein, we briefly describe the strengths and limitations of PET and MRI modalities and highlight the need for the development of multimodal molecularly-targeted agents. We have tried to thoroughly summarize data on bimodal probes available on PubMed. Emphasis was placed on their design, safety profiles, pharmacokinetics, and clearance properties. The challenges in PET/MR probe development using a number of illustrative examples are also discussed, along with future research directions for these novel conjugates.

Keywords

medical imaging; bioresponsive probes; targeting; contrast agents; relaxivity; clearance

Authors

KASTELIK-HRYNIEWIECKA, A.; JEWULA, P.; BAKALORZ, K.; KRAMER-MAREK, G.; KUŹNIK, N.

Released

14. 1. 2022

Publisher

Dove Medical Press

Location

ALBANY

ISBN

1178-2013

Periodical

International Journal of Nanomedicine

Year of study

16

Number

1

State

New Zealand

Pages from

8465

Pages to

8493

Pages count

19

URL

https://www.dovepress.com/targeted-petmri-imaging-super-probes-a-critical-review-of-opportunitie-peer-reviewed-fulltext-article-IJN

Full text in the Digital Library

http://hdl.handle.net/11012/203917

BibTex

@article{BUT175939,
  author="Anna {Kastelik-Hryniewiecka} and Pawel {Jewula} and Karolina {Bakalorz} and Gabriela {Kramer-Marek} and Nikodem {Kuźnik}",
  title="Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges",
  journal="International Journal of Nanomedicine",
  year="2022",
  volume="16",
  number="1",
  pages="8465--8493",
  doi="10.2147/IJN.S336299",
  issn="1178-2013",
  url="https://www.dovepress.com/targeted-petmri-imaging-super-probes-a-critical-review-of-opportunitie-peer-reviewed-fulltext-article-IJN"
}