Detail publikace

Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges

KASTELIK-HRYNIEWIECKA, A. JEWULA, P. BAKALORZ, K. KRAMER-MAREK, G. KUŹNIK, N.

Originální název

Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Recently, the demand for hybrid PET/MRI imaging techniques has increased significantly, which has sparked the investigation into new ways to simultaneously track multiple molecular targets and improve the localization and expression of biochemical markers. Multimodal imaging probes have recently emerged as powerful tools for improving the detection sensitivity and accuracy-both important factors in disease diagnosis and treatment; however, only a limited number of bimodal probes have been investigated in preclinical models. Herein, we briefly describe the strengths and limitations of PET and MRI modalities and highlight the need for the development of multimodal molecularly-targeted agents. We have tried to thoroughly summarize data on bimodal probes available on PubMed. Emphasis was placed on their design, safety profiles, pharmacokinetics, and clearance properties. The challenges in PET/MR probe development using a number of illustrative examples are also discussed, along with future research directions for these novel conjugates.

Klíčová slova

medical imaging; bioresponsive probes; targeting; contrast agents; relaxivity; clearance

Autoři

KASTELIK-HRYNIEWIECKA, A.; JEWULA, P.; BAKALORZ, K.; KRAMER-MAREK, G.; KUŹNIK, N.

Vydáno

14. 1. 2022

Nakladatel

Dove Medical Press

Místo

ALBANY

ISSN

1178-2013

Periodikum

International Journal of Nanomedicine

Ročník

16

Číslo

1

Stát

Nový Zéland

Strany od

8465

Strany do

8493

Strany počet

19

URL

https://www.dovepress.com/targeted-petmri-imaging-super-probes-a-critical-review-of-opportunitie-peer-reviewed-fulltext-article-IJN

Plný text v Digitální knihovně

http://hdl.handle.net/11012/203917

BibTex

@article{BUT175939,
  author="Anna {Kastelik-Hryniewiecka} and Pawel {Jewula} and Karolina {Bakalorz} and Gabriela {Kramer-Marek} and Nikodem {Kuźnik}",
  title="Targeted PET/MRI Imaging Super Probes: A Critical Review of Opportunities and Challenges",
  journal="International Journal of Nanomedicine",
  year="2022",
  volume="16",
  number="1",
  pages="8465--8493",
  doi="10.2147/IJN.S336299",
  issn="1178-2013",
  url="https://www.dovepress.com/targeted-petmri-imaging-super-probes-a-critical-review-of-opportunitie-peer-reviewed-fulltext-article-IJN"
}