Different concepts for creating antibacterial yet biocompatible surfaces: Adding bactericidal element, grafting therapeutic agent through COOH plasma polymer and their combination

journal article in Web of Science

English

Antibacterial coatings have become a rapidly developing field of research, strongly stimulated by the increasing urgency of identifying alternatives to the traditional administration of antibiotics. Such coatings can be deposited onto implants and other medical devices and prevent the inflammations caused by hospital-acquired infections. Nevertheless, the design of antibacterial yet biocompatible and bioactive surfaces is a challenge that biological community has faced for many years but the "materials of dream" have not yet been developed. In this work, the biocompatible yet antibacterial multi-layered films were prepared by a combination of magnetron sputtering (TiCaPCON film), ion implantation (Ag-doped TiCaPCON film), plasma polymerization (COOH layer), and the final immobilization of gentamicin (GM) and heparin (Hepa) molecules. The layer chemistry was thoroughly investigated by means of FTIR and X-ray photoelectron spectroscopies. It was found that the immobilization of therapeutic components occurs throughout the entire thickness of the plasma-deposited COOH layer. The influence of each type of bactericide (Ag+ ions, GM, and Hepa) on antibacterial activity and cell proliferation was analyzed. Our films were cytocompatible and demonstrated superior bactericidal efficiency toward antibioticresistant bacterial E. coli K261 strain. Increased toxicity while using the combination of Ag nanoparticles and COOH plasma polymer is discussed.

Antibacterial surfaces; Plasma; Gentamicin; Silver; Heparin; XPS

PERMYAKOVA, E.; MANAKHOV, A.; KIRYUKHANTSEV-KORNEEV, P.; SHEVEYKO, A.; GUDZ, K.; KOVALSKII, A.; POLČÁK, J.; ZHITNYAK, I.; GLOUSHANKOVA, N.; DYATLOV, I.; IGNATOV, S.; ERSHOV, S.; SHTANSKY, D.

1. 8. 2021

ELSEVIER

AMSTERDAM

0169-4332

Applied Surface Science

556

1

Kingdom of the Netherlands

149751-1

149751-11

11

https://www.sciencedirect.com/science/article/pii/S0169433221008278?via%3Dihub

http://hdl.handle.net/11012/201752

2021 (Polčák) Different concepts for creating antibacterial yet biocompatible surfaces.pdf