Publication detail

Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference

Missey, F. Ejneby, M.S. Ngom, I. Donahue, M. Trajlinek, J. Acerbo, E. Botzanowski, B. Cassarà, A. Neufeld, E. Glowacki, E.D. Shangold, L. Hanes, W.M.

Original Title

Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference

Type

journal article in Scopus

Language

English

Original Abstract

Background: Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, temporal interference stimulation, can overcome depth and focality issues. Methods: Here, we implement a novel form of temporal interference, bilateral temporal interference stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement. Results: Comparing bilateral temporal interference stimulation with unilateral temporal interference stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation. Conclusions: During first-in-man studies, temporal interference stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea. These results suggest a high clinical potential for the use of temporal interference in the treatment of obstructive sleep apnea and other diseases as a safe, effective, and patient-friendly approach.

Keywords

Hypoglossal nerve; Obstructive sleep apnea; Peripheral nerve stimulation; Temporal interference

Authors

Missey, F.; Ejneby, M.S.; Ngom, I.; Donahue, M.; Trajlinek, J.; Acerbo, E.; Botzanowski, B.; Cassarà, A.; Neufeld, E.; Glowacki, E.D.; Shangold, L.; Hanes, W.M.

Released

1. 12. 2023

ISBN

2332-8886

Periodical

Bioelectronic Medicine

Year of study

9

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages count

12

URL

https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00120-7

BibTex

@article{BUT187843,
  author="Missey, F. and Ejneby, M.S. and Ngom, I. and Donahue, M. and Trajlinek, J. and Acerbo, E. and Botzanowski, B. and Cassarà, A. and Neufeld, E. and Glowacki, E.D. and Shangold, L. and Hanes, W.M.",
  title="Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference",
  journal="Bioelectronic Medicine",
  year="2023",
  volume="9",
  number="1",
  pages="12",
  doi="10.1186/s42234-023-00120-7",
  issn="2332-8886",
  url="https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00120-7"
}