Course detail

General Toxicology

FCH-BAA_OBTAcad. year: 2010/2011

The science of toxicology. Terminology of toxicology, History. The explanation of the relation of dose - effec, mechamism of toxic effects, factors influencing toxic effects, characteristics of of toxic effects, basic principles. The chemical compounds interaction. Mechanism of chemical compounds penetrating to organism. Toxicologic kinetice (primary contact, absorption, transport, excretion). The biotransformation of toxic compounds, factors influencing the biotransformation. The causation of demage of cells, tissues, organism and species levels. The main types of toxic effects. The evaluation of toxicity. The summary of the toxicology of inorganic and organic elements, compounds. The view of therapy, antidots. The classification of chemical compounds in CZ and EU, actual legislative. The sources of information, the information system of toxicology.

Language of instruction

English

Number of ECTS credits

2

Mode of study

Not applicable.

Guarantor

Mgr. Helena Doležalová Weissmannová, Ph.D.

Department

Institute of Chemistry and Technology of Environmental Protection (ÚCHTOŽP)

Offered to foreign students

Of all faculties

Learning outcomes of the course unit

Definitions and aplications in toxicology. Toxic effects. Basic factors of influence on toxic effects. View in the field of pollutants a toxic agents.

Prerequisites

Basic knowledges of chemistry, biology and ecology.

Co-requisites

Not applicable.

Planned learning activities and teaching methods

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Assesment methods and criteria linked to learning outcomes

Examination - written and oral part (range of lectures and recommended literature).

Course curriculum

1. The term toxicology within the context of natural sciences, basic definitions, history. The classification of toxicology and basic chararcteristics of toxicological disciplines.
2. Definitions of terms. Toxicity - toxic compounds, toxicological indexes. Toxic effect (type and chararcteristics).
3. Expositions. Dose - relation of dose and effects. toxicological interactions of chemicals.
4. Factors influencing toxic effects (physical, chemical, biological factors).
5. Toxicology on the level of cell, organs, organism, species. The transport across biomembranes.
6. Toxokinetics - interaction of toxic compounds with organism (primary contact, absorption, distribution and transport of ctoxic compounds in organisms, excretion).
7. The basic principles of biotransformation, phase and factors influencing of biotransformation.
8. The toxic effects on organ level (mechanismus, manifestation).
9. Mutagenesis, carcinogenesis, teratogenesis, karcinogeneze, reproductive and developmental toxicity.
10. The evaluation of toxicity.
11. The basic toxicologicl chararcteristics of inorganic and organic compounds.
12. The view of therapy, antidots. The chemical legislation in Czech Republic and EU, toxicological classification of chemicals and compounds. Sources of information in toxicology.

Work placements

Not applicable.

Aims

The explanation of basic terms of toxicology, ecotoxicology. Toxic Effect of toxic agents (cell, organ, species toxicity). Basic factors influencing of toxic effects. The view of toxicological chararcteristics of inorganic, organic compounds. The chemical legislation in Czech Republic and EU.

Specification of controlled education, way of implementation and compensation for absences

Consultations for students in distant form.
Consultations for students.

Recommended optional programme components

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995 (EN)
Doležalová: Elearningové studijní opory, https://www.vutbr.cz/elearning/course (EN)

Recommended reading

Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (EN)
Matrka M., Rusek V., Průmyslová toxikologie, Úvod do obecné a speciální toxikologie Univerzita Pardubice, 1994 (EN)

Classification of course in study plans

  • Programme BPCP_CHCHT_INT Bachelor's

    branch BPCO_CHTOZP , 1. year of study, summer semester, compulsory
    branch BPCO_CHM , 1. year of study, summer semester, compulsory

  • Programme NPCP_CHM_INT Master's

    branch NPCO_CHM , 1. year of study, summer semester, compulsory

  • Programme CKCP_CZV lifelong learning

    branch CKCO_CZV , 1. year of study, summer semester, compulsory

Type of course unit

 

Lecture

26 hours, optionally

Teacher / Lecturer

Mgr. Helena Doležalová Weissmannová, Ph.D.