Contemporary rule of law in the field of hazardous chemical substances and chemical preparations (law, executive notices, methodical directions). Physical, physical-chemical, chemical and toxicological properties of hazardous chemical substances. Mines of informations on dangerous chemical substances (safety data sheet, toxicological and other professional literature, databases on hazardous chemical substances. Hazardous chemical intervention symptoms at persons. First aid at intervention by hazardous chemical substances. Safety work in chemical laboratory with concentration on safety handling with hazardous chemical substances. Fundamental rules of safety handling with hazardous chemical substances and preparations in industry, warehouses, at transport, manipulation and others activities. Basic effects of hazardous chemical substances at accidents and possibility of modelling theirs impacts.