Czech

2

Not applicable.

Definitions and aplications in toxicology. Toxic effects. Basic factors of influence on toxic effects. View in the field of pollutants a toxic agents.

Basic knowledges of chemistry, biology and ecology.

Not applicable.

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Examination - written and oral part (range of lectures and recommended literature).

1. The term toxicology within the context of natural sciences, basic definitions, history. The classification of toxicology and basic chararcteristics of toxicological disciplines.
2. Definitions of terms. Toxicity - toxic compounds, toxicological indexes. Toxic effect (type and chararcteristics).
3. Expositions. Dose - relation of dose and effects. toxicological interactions of chemicals.
4. Factors influencing toxic effects (physical, chemical, biological factors).
5. Toxicology on the level of cell, organs, organism, species. The transport across biomembranes.
6. Toxokinetics - interaction of toxic compounds with organism (primary contact, absorption, distribution and transport of ctoxic compounds in organisms, excretion).
7. The basic principles of biotransformation, phase and factors influencing of biotransformation.
8. The toxic effects on organ level (mechanismus, manifestation).
9. Mutagenesis, carcinogenesis, teratogenesis, karcinogeneze, reproductive and developmental toxicity.
10. The evaluation of toxicity.
11. The basic toxicologicl chararcteristics of inorganic and organic compounds.
12. The view of therapy, antidots. The chemical legislation in Czech Republic and EU, toxicological classification of chemicals and compounds. Sources of information in toxicology.

Not applicable.

The explanation of basic terms of toxicology, ecotoxicology. Toxic Effect of toxic agents (cell, organ, species toxicity). Basic factors influencing of toxic effects. The view of toxicological chararcteristics of inorganic, organic compounds. The chemical legislation in Czech Republic and EU.

Consultations for students in distant form.
Consultations for students.

Not applicable.

Not applicable.

Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (CS)
Lullman, H., Mohr, K., Wehling, M., Farmakologie a toxikologie, Grada vicenum, 2002 (CS)
Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995 (CS)

Matrka M., Rusek V., Průmyslová toxikologie, Úvod do obecné a speciální toxikologie Univerzita Pardubice, 1994 (CS)

26 hours, optionally