Project detail

Self-assembling colloids hyaluronan-surfactant, hyaluronan-amino acid for nanomedical applications

Duration: 01.04.2008 — 30.11.2011

Funding resources

Ministerstvo školství, mládeže a tělovýchovy ČR - COST

- part funder (2008-04-01 - 2011-11-30)

On the project

Projekt studuje fyzikálně-chemické interakce hyaluronan-tenzid a hyaluronan-aminokyselina ve vodném prostředí. Soustředí se zejména na biokompatibilní tenzidy a aminokyseliny s povrchově aktivními vlastnostmi. Účelem projektu je nalézt v uvedených systémech asociativní koloidy schopné solubilizovat hydrofobní látky, které by byly vhodnými kandidáty pro cílenou distribuci nepolárních aktivních látek, zejména léčiv. Dále projekt rozvine aplikaci ultrazvukové spektroskopie s vysokým rozlišením v oblasti studia interakcí biopolymer-tenzid.

Description in English
Project is focused on study of physico-chemical interactions in hyaluronan-surfactant and hyaluronan-amino acid systems. Interactions in these systems should result in formation of self-assembling structures that can be used in the targeted delivery of hydrophobic active substances, drugs, in particular. Hydrophilic, highly hydrated hyaluronan chain which has a specific biological function, which is recognized and bound by cells through specific receptors plays the role of transporting and targeting agent. Surfactants or amino acids should provide non-polar domains solubilizing the hydrophobic substance. In particular, biocompatible surfactants like polar lipids or acylglycosides will be investigated. Simple amino acids will be used to obtain basic information on hyaluronan-amino acid interactions whereas alkylated (acylated) amino acids and betaine surfactants will be used in the development of the carrier systems. Physico-chemical interactions between hyaluronan chain and surfactant/amino acid aggregates (micelles), containing the solubilized hydrophobe, will form the final delivery system, which, at the target, will decompose to its biodegradable constituents. Study on influence of temperature, pH and ionic strength is included. Further, the project will develop applications of the high resolution ultrasound spectroscopy in research of biopolymer-surfactant interactions.

Keywords
aminokyselina, asociativní koloidy, cílená distribuce, hyaluronan, tenzid

Key words in English
amino acid, self-assembling colloids, hyaluronan, surfactant, targeted delivery

Mark

OC08004

Default language

Czech

People responsible

Pekař Miloslav, prof. Ing., CSc. - principal person responsible

Units

Faculty of Chemistry
- beneficiary (2008-04-01 - not assigned)

Results

KROUSKÁ, J.; HALASOVÁ, T.; MRAVEC, F.; PEKAŘ, M. Surface tension and fluorescence probe study of hyaluronan - surfactant system. In IX. Pracovní setkání fyzikálních chemiků a elektrochemiků. Brno: 2009. p. 87-88. ISBN: 978-80-7375-309-2.
Detail

KROUSKÁ, J.; HALASOVÁ, T.; MRAVEC, F.; PEKAŘ, M. Determination of critical micelle concentration in hyaluronan - surfactant system. ChemZi, 2009, vol. 9, no. 5, p. 133-134. ISSN: 1336-7242.
Detail

KRUTIŠOVÁ, T.; HALASOVÁ, T.; MRAVEC, F.; PEKAŘ, M. Influence of the preparing of a biopolymer-surfactant system on its aggregation behavior. Praha: ECIS, 2010. p. P2.57 (P2.57 p.)
Detail

MAIVALDOVÁ, I.; HALASOVÁ, T.; MRAVEC, F.; KLUČÁKOVÁ, M.; PEKAŘ, M. Interaction between phospholipids and hyaluronan - a fluorescence probe study. Praha: ECIS, 2010. p. P7.6 (P7.6 p.)
Detail

KROUSKÁ, J.; HALASOVÁ, T.; MRAVEC, F.; PEKAŘ, M. Effect of hyaluronan on tenside micellization. 2009.
Detail

KROUSKÁ, J.; PEKAŘ, M. Surface tension of hyaluronan-surfactant systems. Elektronický sborník. Berlín: TU Berlín, 2011.
Detail

MRAVEC, F.; KLUČÁKOVÁ, M.; PEKAŘ, M. Fluorescence Spectroscopy Study of Hyaluronan-Phospholipid Interactions. In Advances in Planar Lipid Bilayers and Liposomes. Burlington: Academic Press, 2011. p. 235-255. ISBN: 978-0-12-387720-8.
Detail

HALASOVÁ, T.; PIHÍKOVÁ, D.; SZEWIECZKOVÁ, J.; MRAVEC, F. Fluorescence probes and microrheology with fluorescent particles in investigation of aggregation behavior in ionic surfactant/non-ionic surfactant/polyelectrolyte system. Strasbourg: 12th International Conference on Methods and Applications of Fluorescence, 2011. p. 232-232.
Detail

HERZOG, M.; KROUSKÁ, J.; PEKAŘ, M. Dynamic tensiometry of hyaluronan-surfactant systems. Chemické listy. Chemické listy. Praha: Czech chemical society, 2011. p. s898 ( p.)ISSN: 0009-2770.
Detail

HEJNÁ, J.; MRAVEC, F.; HALASOVÁ, T.; PEKAŘ, M. INFLUENCE OF PH ON SYSTEM CONTAINING ANIONIC POLYELECTROLYTE AND CATIONIC OR NONIONIC SURFACTANT. Chemické listy. Brno: 2011. p. 903-903. ISSN: 0009-2770.
Detail

HALASOVÁ, T.; MRAVEC, F.; PEKAŘ, M. Interactions between hyaluronan and CTAB studied by fluorescence spectroscopy. Berlín: 25th Europian Colloid and Interface Society, 2011. p. T-137 (T-137 p.)
Detail

KLUČÁKOVÁ, M.; PEKAŘ, M. Interactions between hyaluronan and CTAB, ISE titration. Berlin: ECIS, 2011. p. 207-207.
Detail

KLUČÁKOVÁ, M.; PEKAŘ, M. Determining surfactant CMC in electrolyte solutions by ultrasound velocimetry. Antalya: ECIS, 2010. p. P.D43.025 (P.D43.025 p.)
Detail

HALASOVÁ, T.; KROUSKÁ, J.; MRAVEC, F.; PEKAŘ, M. Hyaluronan-surfactant interactions in physiological solution studied by tensiometry and fluorescence probe techniques. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2011, vol. 391, no. 1-3, p. 25-31. ISSN: 0927-7757.
Detail

Responsibility: Pekař Miloslav, prof. Ing., CSc.