Project detail

COMPUTATIONAL MODELLING OF RUPTURE RISK OF ATHEROSCLEROTIC PLAQUES IN CAROTID ARTERIES

Duration: 01.01.2018 — 31.12.2020

Funding resources

Czech Science Foundation - Standardní projekty

- whole funder (2018-01-01 - 2020-12-31)

On the project

Návrh projektu řeší posouzení rizika ruptury (porušení) aterosklerotických plátů v krčních tepnách, jež vede k trombotizaci a mozkové mrtvici. Predikce ruptury je založena na výpočtovém modelování tepny s aterosklerotickým plátem využívajícím její individuální geometrii vytvořenou pomocí magnetické rezonance. Nezatížený tvar bude rekonstruován metodou zpětných přírůstků a zbytková napětí zahrnuta metodou objemového růstu. Anizotropní konstitutivní modely fibrózního krytu plátu a intimy budou kromě mechanických zkoušek využívat znalosti o uspořádání kolagenních vláken, získané matematickou analýzou obrazů histologických řezů snímaných v normálním i polarizovaném světle pomocí rychlé Fourierovy transformace a fázové korelace. Pro určení pravděpodobnosti ruptury plátu bude prováděno stochastické porovnání distribuce napětí vypočtených individualizovaným modelem s hodnotami pevnosti korelovanými s individuálními daty pacienta. Výsledný pravděpodobnostní index ruptury poskytne chirurgům míru rizika porušení plátu pro rozhodování o potřebném zákroku u karotid s podkritickou mírou stenózy.

Description in English
The proposal deals with rupture risk estimation of atherosclerotic plaques in carotid arteries which evokes thrombotization and stroke. The rupture prediction is based on computational modelling of artery with plaque using patient-specific geometry reconstructed from magnetic resonance imaging. The unloaded shape is reconstructed using backward incremental method and residual stresses are included using volumetric growth method. Anisotropic constitutive models of fibrous cap and intima will, beside mechanical tests, exploit knowledge on arrangement of collagen fibres acquired by mathematical image analysis of histological images recorded in brightfield and polarized light using fast Fourier transform and phase correlation. For assessment of plaque rupture risk, we apply stochastic comparison of stress distribution from the individualized model with strength values correlated with patient-specific data. The resulting probability index of rupture offers a measure of rupture risk to the surgeons in making decisions on the needed treatment of carotid arteries with subcritical stenosis.

Keywords
Výpočtové modelování;konstitutivní model;anizotropie;riziko porušení;kolagenní vlákno; aterosklerotický plát;krční tepna

Key words in English
Computational modelling, constitutive model, anisotropy, failure risk, collagen fibre, atherosclerotic plaque, carotid artery

Mark

GA18-13663S

Default language

Czech

People responsible

Staffa Robert, prof. MUDr., Ph.D. - fellow researcher
Burša Jiří, prof. Ing., Ph.D. - principal person responsible

Units

Institute of Solid Mechanics, Mechatronics and Biomechanics
- beneficiary (2018-01-01 - 2020-12-31)

Results

BANSOD, Y.; JAKKA, V.; BURŠA, J. Bendo-tensegrity model simulates compression test of animal cell. In Engineering Mechanics 2018. 2018. p. 45-48. ISBN: 978-80-86246-88-8.
Detail

LISICKÝ, O.; HRUBANOVÁ, A.; STAFFA, R.; VLACHOVSKÝ, R.; BURŠA, J. Constitutive models and failure properties of fibrous tissues of carotid artery atheroma based on their uniaxial testing. JOURNAL OF BIOMECHANICS, 2021, vol. 129, no. 1, p. 110861-1 (110861-8 p.)ISSN: 0021-9290.
Detail

LISICKÝ, O.; POLZER, S.; BURŠA, J. Impact of backbone on stresses in abdominal aortic aneurysms. 2018.
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SKÁCEL, P.; BURŠA, J. Compressibility of arterial wall – direct measurement and predictions of compressible constitutive models. Journal of the mechanical behavior of biomedical materials, 2019, vol. 90, no. 1, p. 538-546. ISSN: 1751-6161.
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LISICKÝ, O.; BURŠA, J. Patient Specific Model of Carotid Artery Bifurcation with Atheroma.
Detail

FISCHER, J.; BURŠA, J. COMPARISON OF VARIOUS DISTRIBUTONS USED FOR COLLAGEN FIBRE ORIENTATIONS IN ARTERIAL LAYERS. In ENGINEERING MECHANICS 2019. 2019. p. 113-116. ISBN: 978-80-87012-71-0.
Detail

LISICKÝ, O.; MALÁ, A.; BURŠA, J. Influence of Transversal Resolution on Reconstructing Atherosclerotic Plaque Components. In VipIMAGE 2019. Porto, Portugalsko: Springer, 2019. p. 501-508. ISBN: 978-3-030-32039-3.
Detail

TURČANOVÁ, M.; HRTOŇ, M.; DVOŘÁK, P.; BURŠA, J. Influnce of Mutual Rotation of Polarizing Filters on Light Intensity Measured with Collagen Fibres. In VipIMAGE 2019. Porto, Portugalsko: Springer, 2019. p. 279-285. ISBN: 978-3-030-32040-9.
Detail

BURŠA, J.; SLAŽANSKÝ, M. Computational investigation of the impact of assumption of affine deformation on constitutive models of soft tissues. Applied andComputational Mechanics, 2019, vol. 13, no. 2, p. 99-106. ISSN: 1802-680X.
Detail

POLZER, S.; POLIŠENSKÁ, A.; NOVÁK, K.; BURŠA, J. Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study. MEDICAL ENGINEERING & PHYSICS, 2019, vol. 69, no. 7, p. 140-146. ISSN: 1350-4533.
Detail

LISICKÝ, O.; MALÁ, A.; BEDNAŘÍK, Z.; NOVOTNÝ, T.; BURŠA, J. Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma. PLOS ONE, 2020, vol. 15, no. 9, p. 1-18. ISSN: 1932-6203.
Detail

JAKKA, V.; BURŠA, J. FINITE ELEMENT MODELS OF MECHANICAL BEHAVIOUR OF ENDOTHELIAL CELLS. In Engineering Mechanics 2020. 2020. p. 222-225. ISBN: 978-80-214-5896-3.
Detail

HRUBANOVÁ, A.; LISICKÝ, O.; BARTOŇOVÁ, P.; STAFFA, R.; HERMANOVÁ, M.; VLACHOVSKÝ, R.; BURŠA, J. IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES. In ENGINEERING MECHANICS 2020. 2020. p. 210-213. ISBN: 978-80-214-5896-3.
Detail

ŠVANCARA, P.; LISICKÝ, O.; JAGOŠ, J.; BURŠA, J. COMPUTATIONAL MODELING OF BLOOD FLOW IN THE BIFURCATION OF HUMAN CAROTID ARTERY. In ENGINEERING MECHANICS 2020. Engineering Mechanics .... 26. 2020. p. 480-483. ISBN: 978-80-214-5896-3. ISSN: 1805-8248.
Detail

FISCHER, J.; BURŠA, J. COMPARISON OF QUALITATIVE CRITERIA IN DECISION ON NUMBER OF COLLAGEN FIBRE FAMILIES IN SOFT TISSUES. In ENGINEERING MECHANICS 2020. 2020. p. 134-137. ISBN: 978-80-214-5896-3.
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JAKKA, V.; BURŠA, J. Finite Element Simulations of Mechanical Behaviour of Endothelial Cells. BioMed Research International, 2021, vol. 2021, no. 1, p. 1-17. ISSN: 2314-6141.
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JAGOŠ, J.; KOHÚT, J.; KOTEK, M.; SKÁCEL, P.; BURŠA, J. Influence of Turbulence in Aorta-like Tube: Computational and Experimental Study. Journal of Applied Fluid Mechanics, 2021, vol. 14, no. 5, p. 1411-1420. ISSN: 1735-3645.
Detail

LISICKÝ, O.; HRUBANOVÁ, A.; BURŠA, J. Interpretation of Experimental Data is Substantial for Constitutive Characterization of Arterial Tissue. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2021, vol. 143, no. 10, p. 104501-1 (104501-6 p.)ISSN: 0148-0731.
Detail

TURČANOVÁ, M.; HRTOŇ, M.; DVOŘÁK, P.; NOVÁK, K.; HERMANOVÁ, M.; BEDNAŘÍK, Z.; POLZER, S.; BURŠA, J. Full-Range Optical Imaging of Planar Collagen Fiber Orientation Using Polarized Light Microscopy. BioMed Research International, 2021, vol. 2021, no. 1, p. 1-13. ISSN: 2314-6141.
Detail

BARTOŇOVÁ, P.; POLZER, S.; BURŠA, J. Definition of principal material directions at irregular arterial shapes. In Engineering Mechanics 2018. Engineering Mechanics .... 2018. p. 57-60. ISBN: 978-80-86246-88-8. ISSN: 1805-8256.
Detail

Responsibility: Burša Jiří, prof. Ing., Ph.D.