Project detail

Influence of infants and children lungs development on flow field and aerosol deposition– computational modelling and experimental validation

Duration: 01.01.2020 — 31.12.2022

Funding resources

Czech Science Foundation - Standardní projekty

- whole funder (2020-02-24 - 2022-12-31)

On the project

The proposed project will focus on the flow field and aerosol transport and deposition in developing infants and children respiratory tract to elucidate whether and how different breathing profiles will impact on the aerosol deposition. Several age groups of infants and children ranging from several weeks until 5 year will be studied in vitro and in silico using computational modelling and experiments. For computational modelling several model will be used, namely RANS models, Large Eddy Simulation and Direct Numerical Simulation. Classical CFD codes based on control volumes will be used linked with Euler-Lagrange and Euler-Euler approach for particles tracking. Also lattice Boltzmann technique in cooperation with Karlsruhe lattice Boltzmann group in Germany will be applied and further developed for LES and DNS simulations. Experimental research will use a unique breathing simulator and several optical diagnostic methods like PDA, LDV and fluorescence technique for particles deposition.

Keywords
infants and children lungs;flow field; aerosol; deposition; computational modelling;experiments; lattice Boltzmann;LES; DNS

Mark

20-27653S

Default language

English

People responsible

Jícha Miroslav, prof. Ing., CSc. - principal person responsible

Units

Energy Institute
- beneficiary (2019-03-28 - not assigned)

Results

MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; LÍZAL, F. Characterization of aerosol nebulized by Aerogen Solo mesh nebulizer. MATEC Web of Conferences, 2020, vol. 328, no. 1, p. 1-7. ISSN: 2261-236X.
Detail

SZABOVÁ, J.; MIŠÍK, O.; HAVLÍKOVÁ, M.; LÍZAL, F.; MRAVEC, F. Influence of liposomes composition on their stability during the nebulization process by vibrating mesh nebulizer. Colloids and Surfaces B: Biointerfaces, 2021, vol. 204, no. 1, p. 1-7. ISSN: 0927-7765.
Detail

MIŠÍK, O.; PEŠTÁLOVÁ, A.; BĚLKA, M.; LÍZAL, F. Nebulizer particle size distribution measured by various methods. Liberec: 2021. p. 119-122.
Detail

PRINZ, F.; ELCNER, J.; POKORNÝ, J.; JÍCHA, M. Lattice Boltzmann Simulation of the Laminar-Turbulent Transition in a Constricted Tube. In 39TH MEETING OF DEPARTMENTS OF FLUID MECHANICS AND THERMODYNAMICS. AIP Conference Proceedings, 2023. p. 1-8. ISBN: 978-0-7354-4325-9.
Detail

BĚLKA, M.; MALÝ, M.; CEJPEK, O.; ELCNER, J.; LÍZAL, F.; JEDELSKÝ, J.; JÍCHA, M. Validated numerical simulation of airflow in child respiratory airways. Liberec: Technical University of Liberec, 2021. p. 1-5.
Detail

PRINZ, F.; POKORNÝ, J.; ELCNER, J.; JÍCHA, M. Lattice Boltzmann Simulation of the Air Flow Through the Children Respiratory Tract. In EFM21 – 15th International Conference “Experimental Fluid Mechanics 2021". EPJ Web of Conferences. Liberec: EDP Sciences, 2022. p. 1-6. ISSN: 2100-014X.
Detail

PRINZ, F.; POKORNÝ, J.; ELCNER, J.; LÍZAL, F.; MIŠÍK, O.; MALÝ, M.; BĚLKA, M.;HAFEN N; KUMMERLÄNDER A.; KRAUSE M.; JEDELSKÝ, J.; JÍCHA, M.;. Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract. COMPUTERS IN BIOLOGY AND MEDICINE, 2024, vol. 170, no. 107994, ISSN: 0010-4825.
Detail

ELCNER, J.; JÍCHA, M. Numerical Study of Flow Field Characteristics in the Trachea During Growth of Human Upper Airways. In 2261-236X. MATEC Web of Conferences. Piešťany: EDP Sciences, 2022. p. 1-7. ISSN: 2261-236X.
Detail

ELCNER, J.; LÍZAL, F.; MIŠÍK, O.; JÍCHA, M. Numerical study of particle deposition in human upper airways during various age periods. Liberec: 2022. p. 1-4.
Detail

MIŠÍK, O.; SZABOVÁ, J.; MRAVEC, F.; LÍZAL, F. Deposition of nebulized liposomal carriers within an upper airways replica. Atény, Grécko: 2022.
Detail

SZABOVÁ, J.; MIŠÍK, O.; FUČÍK, J.; MRÁZOVÁ, K.; MRAVCOVÁ, L.; ELCNER, J.; LÍZAL, F.; KRZYZANEK, V.; MRAVEC, F. Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, vol. 634, no. march, p. 1-12. ISSN: 0378-5173.
Detail

PRINZ, F.; POKORNÝ, J.; ELCNER, J.; JÍCHA, M. LBM simulation of the particle deposition in the children airways with the use of OpenLB. 5th Spring School Lattice Boltzmann Methodswith OpenLB Software Lab, Kraków, Poland: 2022. p. 1 (1 s.).
Detail

MOTIEI, M.; MIŠÍK, O.; THANH HUONG, T.; LÍZAL, F.; HUMPOLÍČEK, P.; SEDLAŘÍK, V.; SÁHA, P. Engineering of inhalable nano-in-microparticles for co-delivery of small molecules and miRNAs. Discover nano, 2023, vol. 18, no. 1, p. 1-16. ISSN: 2731-9229.
Detail

LÍZAL, F.; ELCNER, J.; BĚLKA, M.; JEDELSKÝ, J.; JÍCHA, M. Experimental and Computational Modelling of Aerosol Transport Using the BUT Benchmark Human Lung Model. ERCOFTAC Bulletin 128, September 2021, 2021, vol. 128, no. 1, p. 36-43. ISSN: 2518-0991.
Detail

Responsibility: Jícha Miroslav, prof. Ing., CSc.