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Project detail
Duration: 01.01.2020 — 31.12.2022
Funding resources
Czech Science Foundation - Standardní projekty
- whole funder (2020-02-24 - 2022-12-31)
On the project
The proposed project will focus on the flow field and aerosol transport and deposition in developing infants and children respiratory tract to elucidate whether and how different breathing profiles will impact on the aerosol deposition. Several age groups of infants and children ranging from several weeks until 5 year will be studied in vitro and in silico using computational modelling and experiments. For computational modelling several model will be used, namely RANS models, Large Eddy Simulation and Direct Numerical Simulation. Classical CFD codes based on control volumes will be used linked with Euler-Lagrange and Euler-Euler approach for particles tracking. Also lattice Boltzmann technique in cooperation with Karlsruhe lattice Boltzmann group in Germany will be applied and further developed for LES and DNS simulations. Experimental research will use a unique breathing simulator and several optical diagnostic methods like PDA, LDV and fluorescence technique for particles deposition.
Keywordsinfants and children lungs;flow field; aerosol; deposition; computational modelling;experiments; lattice Boltzmann;LES; DNS
Mark
20-27653S
Default language
English
People responsible
Jícha Miroslav, prof. Ing., CSc. - principal person responsible
Units
Energy Institute- beneficiary (2019-03-28 - not assigned)
Results
MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; LÍZAL, F. Characterization of aerosol nebulized by Aerogen Solo mesh nebulizer. MATEC Web of Conferences, 2020, vol. 328, no. 1, p. 1-7. ISSN: 2261-236X.Detail
SZABOVÁ, J.; MIŠÍK, O.; HAVLÍKOVÁ, M.; LÍZAL, F.; MRAVEC, F. Influence of liposomes composition on their stability during the nebulization process by vibrating mesh nebulizer. Colloids and Surfaces B: Biointerfaces, 2021, vol. 204, no. 1, p. 1-7. ISSN: 0927-7765.Detail
MIŠÍK, O.; PEŠTÁLOVÁ, A.; BĚLKA, M.; LÍZAL, F. Nebulizer particle size distribution measured by various methods. Liberec: 2021. p. 119-122.Detail
PRINZ, F.; ELCNER, J.; POKORNÝ, J.; JÍCHA, M. Lattice Boltzmann Simulation of the Laminar-Turbulent Transition in a Constricted Tube. In 39TH MEETING OF DEPARTMENTS OF FLUID MECHANICS AND THERMODYNAMICS. AIP Conference Proceedings, 2023. p. 1-8. ISBN: 978-0-7354-4325-9.Detail
BĚLKA, M.; MALÝ, M.; CEJPEK, O.; ELCNER, J.; LÍZAL, F.; JEDELSKÝ, J.; JÍCHA, M. Validated numerical simulation of airflow in child respiratory airways. Liberec: Technical University of Liberec, 2021. p. 1-5.Detail
PRINZ, F.; POKORNÝ, J.; ELCNER, J.; JÍCHA, M. Lattice Boltzmann Simulation of the Air Flow Through the Children Respiratory Tract. In EFM21 – 15th International Conference “Experimental Fluid Mechanics 2021". EPJ Web of Conferences. Liberec: EDP Sciences, 2022. p. 1-6. ISSN: 2100-014X.Detail
PRINZ, F.; POKORNÝ, J.; ELCNER, J.; LÍZAL, F.; MIŠÍK, O.; MALÝ, M.; BĚLKA, M.;HAFEN N; KUMMERLÄNDER A.; KRAUSE M.; JEDELSKÝ, J.; JÍCHA, M.;. Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract. COMPUTERS IN BIOLOGY AND MEDICINE, 2024, vol. 170, no. 107994, ISSN: 0010-4825.Detail
ELCNER, J.; JÍCHA, M. Numerical Study of Flow Field Characteristics in the Trachea During Growth of Human Upper Airways. In 2261-236X. MATEC Web of Conferences. Piešťany: EDP Sciences, 2022. p. 1-7. ISSN: 2261-236X.Detail
ELCNER, J.; LÍZAL, F.; MIŠÍK, O.; JÍCHA, M. Numerical study of particle deposition in human upper airways during various age periods. Liberec: 2022. p. 1-4.Detail
MIŠÍK, O.; SZABOVÁ, J.; MRAVEC, F.; LÍZAL, F. Deposition of nebulized liposomal carriers within an upper airways replica. Atény, Grécko: 2022.Detail
SZABOVÁ, J.; MIŠÍK, O.; FUČÍK, J.; MRÁZOVÁ, K.; MRAVCOVÁ, L.; ELCNER, J.; LÍZAL, F.; KRZYZANEK, V.; MRAVEC, F. Liposomal Form of Erlotinib for Local Inhalation Administration and Efficiency of Its Transport to the Lungs. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, vol. 634, no. march, p. 1-12. ISSN: 0378-5173.Detail
PRINZ, F.; POKORNÝ, J.; ELCNER, J.; JÍCHA, M. LBM simulation of the particle deposition in the children airways with the use of OpenLB. 5th Spring School Lattice Boltzmann Methodswith OpenLB Software Lab, Kraków, Poland: 2022. p. 1 (1 s.).Detail
MOTIEI, M.; MIŠÍK, O.; THANH HUONG, T.; LÍZAL, F.; HUMPOLÍČEK, P.; SEDLAŘÍK, V.; SÁHA, P. Engineering of inhalable nano-in-microparticles for co-delivery of small molecules and miRNAs. Discover nano, 2023, vol. 18, no. 1, p. 1-16. ISSN: 2731-9229.Detail
LÍZAL, F.; ELCNER, J.; BĚLKA, M.; JEDELSKÝ, J.; JÍCHA, M. Experimental and Computational Modelling of Aerosol Transport Using the BUT Benchmark Human Lung Model. ERCOFTAC Bulletin 128, September 2021, 2021, vol. 128, no. 1, p. 36-43. ISSN: 2518-0991.Detail