In this project, I am going to investigate morphogenesis of a muscle group that does not have bone-to-bone attachments and constitute an evolutionary conserved cranial muscle unit - the extraocular muscles (EOMs). These muscles are responsible for the coordinated movement of the eyeballs and vision. The aim of this project is to build a precise spatiotemporal map of EOM patterning from their emergence as a unique anlage. This would help to understand how myogenic cells integrate with connective tissue, tendons and attachment points to form a functional unit.

CEITEC VUT-J-20-6317

Czech

Kaiser Markéta, Ing., Ph.D. - principal person responsible
Zikmund Tomáš, doc. Ing., Ph.D. - fellow researcher

Advanced instrumentation and methods for material characterization
- responsible department (5.3.2020 - not assigned)
Advanced instrumentation and methods for material characterization
- co-beneficiary (1.1.2020 - 31.12.2020)
Central European Institute of Technology BUT
- beneficiary (1.1.2020 - 31.12.2020)

MATULA, J.; TESAŘOVÁ, M.; ZIKMUND, T.; KAUCKÁ, M.; ADAMEYKO, I.; KAISER, J. X-ray microtomography–based atlas of mouse cranial development. GigaScience, 2021, vol. 10, no. 3, p. 1-6. ISSN: 2047-217X.
Detail

COMAI, G.; TESAŘOVÁ, M.; DUPÉ, V.; RHINN, M.; VALLECILLO-GARCÍA, P.; DA SILVA, F.; FERET, B.; EXELBY, K.; DOLLE, P.; CARLSSON, L.; PRYCE, B.; SPITZ, F.; STRICKER, S.; ZIKMUND, T.; KAISER, J.; BRISCOE, J.; SCHEDL, A.; GHYSELINCK, N.; SCHWEITZER, R.; TAJBAKHSH, S. Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLOS BIOLOGY, 2020, vol. 18, no. 11, p. 1-33. ISSN: 1544-9173.
Detail

Responsibility: Kaiser Markéta, Ing., Ph.D.