Project detail

Multi-Contrast Quantification of Perfusion Using Joint Magnetic Resonance Contrast-Enhanced and Arterial-Spin-Labeling Approaches

Duration: 01.01.2022 — 31.12.2024

Funding resources

Czech Science Foundation - Standardní projekty

- whole funder

On the project

Magnetic resonance (MR) perfusion imaging is used for diagnostics and therapy monitoring mostly in oncology, neurology and cardiology, providing assessment of the perfusion status of a tissue on the capillary level. However, current MR perfusion imaging methods are still not ready for routine clinical use. They still remain mostly on the experimental level. The main methods for MR perfusion imaging are Dynamic Contrast-Enhanced (DCE) MRI, Dynamic Susceptibility- Contrast (DSC) MRI and Arterial Spin Labeling (ASL). So far, they have been treated as competing methods and compared among each other to find the best one. In this project, we propose a very different approach that might push MR perfusion imaging towards a reliable reproducible measurement method. We propose a connection of these MR perfusion imaging approaches using a joint approach. We will develop advanced interconnected pharmacokinetic models, compressed-sensing MR acquisition and image reconstruction schemes that utilize the complementary information provided by these three methods.

Keywords
magnetic resonance;perfusion;pharmacokinetic modeling;optimization;regularization; compressed sensing

Mark

22-10953S

Default language

English

People responsible

Mangová Marie, Ing., Ph.D. - fellow researcher
Mokrý Ondřej, Ing., Ph.D. - fellow researcher
Rajmic Pavel, prof. Mgr., Ph.D. - principal person responsible

Units

Department of Telecommunications
- co-beneficiary (2022-01-01 - 2024-12-31)
The Czech Academy of Sciences
- beneficiary (2022-01-01 - 2024-12-31)

Results

VITOUŠ, J.; JIŘÍK, R.; STRAČINA, T.; HENDRYCH, M.; NÁDENÍČEK, J.; MACÍČEK, O.; TIAN, Y.; KRÁTKÁ, L.; DRAŽANOVÁ, E.; NOVÁKOVÁ, M.; BABULA, P.; PANOVSKÝ, R.; DIBELLA, E.; STARČUK, Z. T1 mapping of myocardium in rats using self-gated golden-angle acquisition. MAGNETIC RESONANCE IN MEDICINE, 2023, vol. 91, no. 1, p. 368-380. ISSN: 0740-3194.
Detail