Project detail

A novel and sensitive approach in electrochemical determination of HER2 a breast cancer biomarker using a nanozyme-aptamer conjugated system

Duration: 01.03.2023 — 28.02.2024

Funding resources

Brno University of Technology - Vnitřní projekty VUT

- whole funder (2023-01-01 - 2024-12-31)

On the project

Breast cancer is a major death cause among cancer types. A phosphatase nanozyme-aptamer integrated system will be built to use in electrochemical determination of HER2, which is a breast cancer biomarker. To this end, nanozymes will be synthesized and modified with HER2 specific aptamer. Electrochemical signal will be produced in presence of HER2 because of the hybridization of aptamer with HER2. The morphology of synthesized nanozyme and aptamer length and sequence will be optimized to reach a high sensitivity in detection of HER2.

Mark

CEITEC VUT-J-23-8395

Default language

Czech

People responsible

Richtera Lukáš, doc. RNDr., Ph.D. - fellow researcher
Garehbaghi Sanam, MEng., M.Sc. - principal person responsible

Units

Central European Institute of Technology BUT
- responsible department (2023-01-31 - 2023-03-06)
Smart Nanodevices
- beneficiary (2023-03-01 - 2024-02-28)

Results

GAREHBAGHI, S.; ADAM, V.; PŘIBYL, J.; RICHTERA, L.; ASHRAFI, A. An enzyme cascade biosensor based on multiwalled carbon nanotube-RuO2 nanocomposite for selective amperometric determination of lactose in milk samples. MICROCHEMICAL JOURNAL, 2024, vol. 204, no. 111138, ISSN: 1095-9149.
Detail

Responsibility: Garehbaghi Sanam, MEng., M.Sc.