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Project detail
Duration: 01.03.2024 — 28.02.2025
Funding resources
Brno University of Technology - Vnitřní projekty VUT
- whole funder (2024-01-01 - 2025-12-31)
On the project
A novel therapeutic option for patients with critical-sized skin wounds has emerged: 3D scaffolds. This project aims to prepare and evaluate a second generation collagen-based scaffold that mimics the dermis of the human skin grafted with hypoxia-inducible factors (HIFs). For the adequate vascularization process dimethyloxalylglycine (DMOG) as HIF will be added to the scaffold to support cell proliferation, angiogenesis and to prevent cell death after application.
KeywordsWound dressing, scaffold, collagen, chitosan, dermis, regenerative medicine, drug release, vascularization
Mark
CEITEC VUT-J-24-8629
Default language
Czech
People responsible
Pavliňáková Veronika, Mgr., Ph.D. - fellow researcherIzsák Dávid, Ing. - principal person responsible
Units
Advanced Biomaterials- (2024-01-01 - 2024-12-31)Central European Institute of Technology BUT- (2024-01-30 - 2024-03-04)
Results
IZSÁK, D.; PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; SZOTKOWSKÁ, T.; BUCHTOVÁ, M.; VOJTOVÁ, L. Advanced 3D collagen-based scaffolds modified with pro-angiogenic molecule for wound healing. Bioimplantologie a regenerativní medicína 2024. Praha: 2024. p. 35-35. ISBN: 978-80-01-07293-6.Detail