Project detail

Advanced HIF-modified 3D collagen-based wound scaffolds for optimal regeneration and vascularization for critical-sized skin defects

Duration: 01.03.2024 — 28.02.2025

Funding resources

Brno University of Technology - Vnitřní projekty VUT

- whole funder (2024-01-01 - 2025-12-31)

On the project

A novel therapeutic option for patients with critical-sized skin wounds has emerged: 3D scaffolds. This project aims to prepare and evaluate a second generation collagen-based scaffold that mimics the dermis of the human skin grafted with hypoxia-inducible factors (HIFs). For the adequate vascularization process dimethyloxalylglycine (DMOG) as HIF will be added to the scaffold to support cell proliferation, angiogenesis and to prevent cell death after application.

Keywords
Wound dressing, scaffold, collagen, chitosan, dermis, regenerative medicine, drug release, vascularization

Mark

CEITEC VUT-J-24-8629

Default language

Czech

People responsible

Pavliňáková Veronika, Mgr., Ph.D. - fellow researcher
Izsák Dávid, Ing. - principal person responsible

Units

Advanced Biomaterials
- beneficiary (2024-01-01 - 2024-12-31)
Central European Institute of Technology BUT
- responsible department (2024-01-30 - 2024-03-04)

Results

IZSÁK, D.; PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; SZOTKOWSKÁ, T.; BUCHTOVÁ, M.; VOJTOVÁ, L. Advanced 3D collagen-based scaffolds enriched with vasculogenic compound for enhanced vascularization and wound healing. 21st International Conference on Nanosciences & Nanotechnologies, Book of Abstract, Greece, Thessaloniki, 2-5 July 2024. Thessaloniki, Greece: 2024. p. 171-171.
Detail

IZSÁK, D.; PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; SZOTKOWSKÁ, T.; BUCHTOVÁ, M.; VOJTOVÁ, L. Advanced 3D collagen-based scaffolds modified with pro-angiogenic molecule for wound healing. Bioimplantologie a regenerativní medicína 2024. Praha: 2024. p. 35-35. ISBN: 978-80-01-07293-6.
Detail

Responsibility: Izsák Dávid, Ing.