The understanding of particle transport and deposition in the human respiratory tract is important to evaluate health concerns from inhaled particulate matter and to precisely target inhalation drug delivery. The deposition has been thoroughly studied in healthy lungs, but it received less attention in diseased lungs, in particular asthmatic lungs. The lung pathology alters not just an airway geometry but also a breathing regime. A properly validated computational fluid and particle dynamics (CFPD) methods can link the specific deposition patterns to the underlying flow dynamics. The realistic airway replica including asthmatic abnormalities will be created. This geometry will be used in both experiments and CFPD simulations. The deposition will be studied for normal tidal breathing and breathing through an inhaler. Local flow features will be determined and their effect on particle behaviour will be explained. The outlet inhaler conditions will be measured to accurately prescribed CFD boundary conditions.

Keywords
asthma;respiratory airways;particle deposition;inhaler;aerosolized medicine

25-16971S

English

Bělka Miloslav, Ing., Ph.D. - principal person responsible

Energy Institute
- responsible department (27.3.2024 - not assigned)
Energy Institute
- beneficiary (27.3.2024 - not assigned)

Responsibility: Bělka Miloslav, Ing., Ph.D.