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CERNEI, N. ZÍTKA, O. SKALIČKOVÁ, S. GUMULEC, J. SZTALMACHOVÁ, M. MERLOS RODRIGO, M. SOCHOR, J. MASAŘÍK, M. ADAM, V. HUBÁLEK, J. TRNKOVÁ, L. KRUSEOVÁ, J. ECKSCHLAGER, T. KIZEK, R.
Original Title
Effect of sarcosine on antioxidant parameters and metallothionein content in the PC-3 prostate cancer cell line
Type
journal article in Web of Science
Language
English
Original Abstract
Sarcosine is currently one of the most discussed markers of prostate cancer. It is involved in amino acid metabolism and methylation processes that occur during the progression of prostate cancer. In this study, we monitored the effect of the addition of sarcosine (0; 10; 250; 500; 1,000 and 1,500 uM) in a time-dependent manner (0-72 h) on the PC-3 prostate cancer cell line. For the assessment of cell viability, the commonly used MTT test was employed. Furthermore, ion-exchange liquid chromatography was used for the determination of sarcosine content in the PC-3 cells
Keywords
sarcosine, prostate cancer, metallothionein, antioxidant activity, chip electrophoresis, ion-exchange chromatography, Brdicka reaction
Authors
CERNEI, N.; ZÍTKA, O.; SKALIČKOVÁ, S.; GUMULEC, J.; SZTALMACHOVÁ, M.; MERLOS RODRIGO, M.; SOCHOR, J.; MASAŘÍK, M.; ADAM, V.; HUBÁLEK, J.; TRNKOVÁ, L.; KRUSEOVÁ, J.; ECKSCHLAGER, T.; KIZEK, R.
RIV year
2013
Released
1. 6. 2013
ISBN
1021-335X
Periodical
ONCOLOGY REPORTS
Year of study
29
Number
6
State
Hellenic Republic
Pages from
2459
Pages to
2466
Pages count
8
BibTex
@article{BUT100725, author="Natalia Vladimirovna {Cernei} and Ondřej {Zítka} and Sylvie {Skaličková} and Jaromír {Gumulec} and Markéta {Sztalmachová} and Miguel Ángel {Merlos Rodrigo} and Jiří {Sochor} and Michal {Masařík} and Vojtěch {Adam} and Jaromír {Hubálek} and Libuše {Trnková} and Jarmila {Kruseová} and Tomáš {Eckschlager} and René {Kizek}", title="Effect of sarcosine on antioxidant parameters and metallothionein content in the PC-3 prostate cancer cell line", journal="ONCOLOGY REPORTS", year="2013", volume="29", number="6", pages="2459--2466", doi="10.3892/or.2013.2389", issn="1021-335X" }