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VACULOVIČOVÁ, M. ŠMERKOVÁ, K. PEKÁRKOVÁ, J. HUBÁLEK, J. ADAM, V. KIZEK, R.
Original Title
Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics
Type
journal article in Web of Science
Language
English
Original Abstract
Cisplatin, carboplatin, and oxaliplatin represent three generations of platinum based drugs applied successfully for cancer treatment. As a consequence of the employment of platinum based cytostatics in the cancer treatment, it became necessary to study the mechanism of their action. Current accepted opinion is the formation of Pt-DNA adducts, but the mechanism of their formation is still unclear. Nanomaterials, as a progressively developing branch, can offer a tool for studying the interactions of these drugs with DNA
Keywords
Capillary electrophoresis, DNA, Gel electrophoresis, Platinum cytostatic drugs, Quantum dots
Authors
VACULOVIČOVÁ, M.; ŠMERKOVÁ, K.; PEKÁRKOVÁ, J.; HUBÁLEK, J.; ADAM, V.; KIZEK, R.
RIV year
2013
Released
1. 3. 2013
Publisher
Wiley
Location
Německo
ISBN
0173-0835
Periodical
Electrophoresis
Year of study
34
Number
6
State
Federal Republic of Germany
Pages from
801
Pages to
808
Pages count
8
BibTex
@article{BUT100726, author="Markéta {Vaculovičová} and Kristýna {Šmerková} and Jana {Pekárková} and Jaromír {Hubálek} and Vojtěch {Adam} and René {Kizek}", title="Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics", journal="Electrophoresis", year="2013", volume="34", number="6", pages="801--808", doi="10.1002/elps.201200664", issn="0173-0835" }