Publication detail

Serum metallothioneins in childhood tumours – A potential prognostic marker

KRUSEOVÁ, J. HYNEK, D. ADAM, V. KIZEK, R. PRŮŠA, R. HRABĚTA, J. ECKSCHLAGER, T.

Original Title

Serum metallothioneins in childhood tumours – A potential prognostic marker

Type

journal article in Web of Science

Language

English

Original Abstract

Metallothioneins (MT) are low molecular weight, cysteine-rich proteins maintaining metal ions homeostasis. They play a role in carcinogenesis and may also cause chemoresistance. The aim of the study was to explore the importance of MT serum levels in children suffering from malignant tumours. This prospective study involves examination of 865 samples from 172 patients with malignant tumours treated from 2008 to 2011 at University Hospital Motol. MT serum levels were determined using differential pulse voltammetry–Brdicka reaction

Keywords

metallothionein, prognostic marker, cysteine, chemoresistance

Authors

KRUSEOVÁ, J.; HYNEK, D.; ADAM, V.; KIZEK, R.; PRŮŠA, R.; HRABĚTA, J.; ECKSCHLAGER, T.

RIV year

2013

Released

6. 6. 2013

Publisher

MDPI

ISBN

1422-0067

Periodical

International Journal of Molecular Sciences

Year of study

14

Number

6

State

Swiss Confederation

Pages from

12170

Pages to

12185

Pages count

16

URL

http://www.mdpi.com/1422-0067/14/6/12170

Full text in the Digital Library

http://hdl.handle.net/11012/70082

BibTex

@article{BUT101188,
  author="Jarmila {Kruseová} and David {Hynek} and Vojtěch {Adam} and René {Kizek} and Richard {Průša} and Jan {Hraběta} and Tomáš {Eckschlager}",
  title="Serum metallothioneins in childhood tumours – A potential prognostic marker",
  journal="International Journal of Molecular Sciences",
  year="2013",
  volume="14",
  number="6",
  pages="12170--12185",
  doi="10.3390/ijms140612170",
  issn="1422-0067",
  url="http://www.mdpi.com/1422-0067/14/6/12170"
}