Publication detail

Comparison of gold nanostructured electrode and flat gold electrode on doxorubicin measurements

KYNCLOVÁ, H. PŘIBYL, J. HRDÝ, R. DRBOHLAVOVÁ, J. PRÁŠEK, J. HUBÁLEK, J.

Original Title

Comparison of gold nanostructured electrode and flat gold electrode on doxorubicin measurements

Type

conference paper

Language

English

Original Abstract

Doxorubicin is a planar aromatic molecule and it is commonly used in cancer chemotherapy. In this study, we compared nanostructured electrodes with gold nanocolumns and flat gold electrodes by measurements with doxorubicin. Nanostructured electrodes were fabricated by electrochemical anodic oxidation when the aluminium layer was transformed to the porous alumina layer. Then gold material was deposited into the pores. After removal of aluminium template the nanostructured surface made of ordered gold nanocolumns on metal underlay was obtained. Flat gold electrodes were fabricated by evaporation of gold layer to the silicon substrate. After that, all electrodes were characterized by electrochemical impedance spectroscopy and then the detection of doxorubicin was studied by differential pulse voltammetry. According to the impedance spectroscopy measurements a bigger electroactive area for nanostructured electrodes was proved. The gold nanocolumns have been found as a significant factor in increasing of electrodes active area. This fact is very important for sensors sensitivity. Fabricated electrodes were successfully used for determination of doxorubicin. Doxorubicin oxidation peak was observed at a potential - 0.6 V.

Keywords

gold nanocolumns, impedance spectroscopy, differential pulse voltammetry, doxorubicin

Authors

KYNCLOVÁ, H.; PŘIBYL, J.; HRDÝ, R.; DRBOHLAVOVÁ, J.; PRÁŠEK, J.; HUBÁLEK, J.

RIV year

2013

Released

16. 10. 2013

Publisher

Tanger, Ltd.

Location

Ostrava

ISBN

978-80-87294-47-5

Book

Conference Proceedings 5th International Conference NANOCON 2013

Pages from

215

Pages to

219

Pages count

5

BibTex

@inproceedings{BUT102059,
  author="Hana {Kynclová} and Jakub {Přibyl} and Radim {Hrdý} and Jana {Drbohlavová} and Jan {Prášek} and Jaromír {Hubálek}",
  title="Comparison of gold nanostructured electrode and flat gold electrode on doxorubicin measurements",
  booktitle="Conference Proceedings 5th International Conference NANOCON 2013",
  year="2013",
  pages="215--219",
  publisher="Tanger, Ltd.",
  address="Ostrava",
  isbn="978-80-87294-47-5"
}