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NYLUND, K. JIŘÍK, R. MÉZL, M. LEH, S. HAUSKEN, T. PFEFFER, F. ODEGAARD, S. TAXT, T. GILJA, O.
Original Title
Quantitative Contrast-Enhanced Ultrasound Comparison Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease
Type
journal article - other
Language
English
Original Abstract
The aim of this study was to determine whether there are differences in absolute blood flow between patients with Crohn's disease with inflammation or fibrosis using contrast-enhanced ultrasound. Eighteen patients with fibrotic disease and 19 patients with inflammation were examined. Video sequences of contrast data were analyzed using a pharmacokinetic model to extract the arterial input and tissue residue functions with a custom software, enabling calculation of the absolute values for mean transit time, blood volume and flow. Feasibility of the examination was 89%. The fibrosis group had lower blood volume (0.9 vs. 3.4 mL per 100 mL tissue; p = 0.001) and flow (22.6 vs. 45.3 mL/min per 100 mL tissue; p = 0.003) compared with the inflammation group. There was no significant difference in mean transit time (3.9 vs. 5.5 s). In conclusion, absolute perfusion measurement in the gastrointestinal wall using contrast-enhanced ultrasound is feasible. There seems to be reduced blood volume and blood flow in patients with fibrotic disease.
Keywords
Crohn's disease; Inflammatory bowel disease; Intestinal blood flow; Ultrasonography
Authors
NYLUND, K.; JIŘÍK, R.; MÉZL, M.; LEH, S.; HAUSKEN, T.; PFEFFER, F.; ODEGAARD, S.; TAXT, T.; GILJA, O.
RIV year
2013
Released
1. 7. 2013
ISBN
0301-5629
Periodical
ULTRASOUND IN MEDICINE AND BIOLOGY
Year of study
39
Number
7
State
United Kingdom of Great Britain and Northern Ireland
Pages from
1197
Pages to
1206
Pages count
10
BibTex
@article{BUT102229, author="Kim {Nylund} and Radovan {Jiřík} and Martin {Mézl} and Sabine {Leh} and Trygve {Hausken} and Frank {Pfeffer} and Svein {Ødegaard} and Torfinn {Taxt} and Odd Helge {Gilja}", title="Quantitative Contrast-Enhanced Ultrasound Comparison Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease", journal="ULTRASOUND IN MEDICINE AND BIOLOGY", year="2013", volume="39", number="7", pages="1197--1206", issn="0301-5629" }