Publication detail

Quantitative Contrast-Enhanced Ultrasound Comparison Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease

NYLUND, K. JIŘÍK, R. MÉZL, M. LEH, S. HAUSKEN, T. PFEFFER, F. ODEGAARD, S. TAXT, T. GILJA, O.

Original Title

Quantitative Contrast-Enhanced Ultrasound Comparison Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease

Type

journal article - other

Language

English

Original Abstract

The aim of this study was to determine whether there are differences in absolute blood flow between patients with Crohn's disease with inflammation or fibrosis using contrast-enhanced ultrasound. Eighteen patients with fibrotic disease and 19 patients with inflammation were examined. Video sequences of contrast data were analyzed using a pharmacokinetic model to extract the arterial input and tissue residue functions with a custom software, enabling calculation of the absolute values for mean transit time, blood volume and flow. Feasibility of the examination was 89%. The fibrosis group had lower blood volume (0.9 vs. 3.4 mL per 100 mL tissue; p = 0.001) and flow (22.6 vs. 45.3 mL/min per 100 mL tissue; p = 0.003) compared with the inflammation group. There was no significant difference in mean transit time (3.9 vs. 5.5 s). In conclusion, absolute perfusion measurement in the gastrointestinal wall using contrast-enhanced ultrasound is feasible. There seems to be reduced blood volume and blood flow in patients with fibrotic disease.

Keywords

Crohn's disease; Inflammatory bowel disease; Intestinal blood flow; Ultrasonography

Authors

NYLUND, K.; JIŘÍK, R.; MÉZL, M.; LEH, S.; HAUSKEN, T.; PFEFFER, F.; ODEGAARD, S.; TAXT, T.; GILJA, O.

RIV year

2013

Released

1. 7. 2013

ISBN

0301-5629

Periodical

ULTRASOUND IN MEDICINE AND BIOLOGY

Year of study

39

Number

7

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1197

Pages to

1206

Pages count

10

BibTex

@article{BUT102229,
  author="Kim {Nylund} and Radovan {Jiřík} and Martin {Mézl} and Sabine {Leh} and Trygve {Hausken} and Frank {Pfeffer} and Svein {Ødegaard} and Torfinn {Taxt} and Odd Helge {Gilja}",
  title="Quantitative Contrast-Enhanced Ultrasound Comparison Between Inflammatory and Fibrotic Lesions in Patients with Crohn's Disease",
  journal="ULTRASOUND IN MEDICINE AND BIOLOGY",
  year="2013",
  volume="39",
  number="7",
  pages="1197--1206",
  issn="0301-5629"
}