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ZÍTKA, O. CERNEI, N. HEGER, Z. MATOUŠEK, M. KOPEL, P. KYNICKÝ, J. MASAŘÍK, M. KIZEK, R. ADAM, V.
Original Title
Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine
Type
journal article in Web of Science
Language
English
Original Abstract
Carcinoma of prostate (CaP) is the second most frequent malignant tumor occurring in men in Europe. Currently there is discussion on a wide range of potential CaP markers. One of them - nonprotein amino acid sarcosine, also known as N-methylglycine was chosen as a challenge for the development of microfluidic system with isolation by modified paramagnetic microparticles. Therefore, the aim of this study was to design a low-cost, simple, and rapidmicrofluidic system based on sarcosine isolation with modified paramagnetic microparticles and subsequent analysis on the ion exchange LC.
Keywords
Ion exchange chromatography, Magnetic nanoparticles, Microfluidic separation, Prostate cancer, Surface modification
Authors
ZÍTKA, O.; CERNEI, N.; HEGER, Z.; MATOUŠEK, M.; KOPEL, P.; KYNICKÝ, J.; MASAŘÍK, M.; KIZEK, R.; ADAM, V.
RIV year
2013
Released
1. 9. 2013
ISBN
0173-0835
Periodical
Electrophoresis
Year of study
34
Number
18
State
Federal Republic of Germany
Pages from
2639
Pages to
2647
Pages count
9
BibTex
@article{BUT103908, author="Ondřej {Zítka} and Natalia Vladimirovna {Cernei} and Zbyněk {Heger} and Miroslav {Matoušek} and Pavel {Kopel} and Jindřich {Kynický} and Michal {Masařík} and René {Kizek} and Vojtěch {Adam}", title="Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine", journal="Electrophoresis", year="2013", volume="34", number="18", pages="2639--2647", doi="10.1002/elps.201300114", issn="0173-0835" }