Publication detail

Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging?

ŠOBROVÁ, P. BLAŽKOVÁ, I. CHOMOUCKÁ, J. DRBOHLAVOVÁ, J. VACULOVIČOVÁ, M. KOPEL, P. HUBÁLEK, J. KIZEK, R. ADAM, V.

Original Title

Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging?

Type

journal article in Web of Science

Language

English

Original Abstract

A diagnostics of infectious diseases can be done by the immunologic methods or by the amplification of nucleic acid specific to contagious agent using polymerase chain reaction. However, in transmissible spongiform encephalopathies, the infectious agent, prion protein (PrPSc), has the same sequence of nucleic acids as a naturally occurring protein. The other issue with the diagnosing based on the PrPSc detection is that the pathological form of prion protein is abundant only at late stages of the disease in a brain. Therefore, the diagnostics of prion protein caused diseases represent a sort of challenges as that hosts can incubate infectious prion proteins for many months or even years. Therefore, new in vivo assays for detection of prion proteins and for diagnosis of their relation to neurodegenerative diseases are summarized. Their applicability and future prospects in this field are discussed with particular aim at using quantum dots as fluorescent labels.

Keywords

imaging; label; neurodegenerative disease; prion protein; quantum dots

Authors

ŠOBROVÁ, P.; BLAŽKOVÁ, I.; CHOMOUCKÁ, J.; DRBOHLAVOVÁ, J.; VACULOVIČOVÁ, M.; KOPEL, P.; HUBÁLEK, J.; KIZEK, R.; ADAM, V.

RIV year

2013

Released

1. 9. 2013

Publisher

LANDES BIOSCIENCE

Location

1806 RIO GRANDE ST, AUSTIN, TX 78702 USA

ISBN

1933-6896

Periodical

PRION

Year of study

7

Number

5

State

United States of America

Pages from

349

Pages to

358

Pages count

10

BibTex

@article{BUT104157,
  author="Pavlína {Adam} and Iva {Blažková} and Jana {Pekárková} and Jana {Drbohlavová} and Markéta {Vaculovičová} and Pavel {Kopel} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}",
  title="Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging?",
  journal="PRION",
  year="2013",
  volume="7",
  number="5",
  pages="349--358",
  doi="10.4161/pri.26524",
  issn="1933-6896"
}