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ŠOBROVÁ, P. BLAŽKOVÁ, I. CHOMOUCKÁ, J. DRBOHLAVOVÁ, J. VACULOVIČOVÁ, M. KOPEL, P. HUBÁLEK, J. KIZEK, R. ADAM, V.
Original Title
Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging?
Type
journal article in Web of Science
Language
English
Original Abstract
A diagnostics of infectious diseases can be done by the immunologic methods or by the amplification of nucleic acid specific to contagious agent using polymerase chain reaction. However, in transmissible spongiform encephalopathies, the infectious agent, prion protein (PrPSc), has the same sequence of nucleic acids as a naturally occurring protein. The other issue with the diagnosing based on the PrPSc detection is that the pathological form of prion protein is abundant only at late stages of the disease in a brain. Therefore, the diagnostics of prion protein caused diseases represent a sort of challenges as that hosts can incubate infectious prion proteins for many months or even years. Therefore, new in vivo assays for detection of prion proteins and for diagnosis of their relation to neurodegenerative diseases are summarized. Their applicability and future prospects in this field are discussed with particular aim at using quantum dots as fluorescent labels.
Keywords
imaging; label; neurodegenerative disease; prion protein; quantum dots
Authors
ŠOBROVÁ, P.; BLAŽKOVÁ, I.; CHOMOUCKÁ, J.; DRBOHLAVOVÁ, J.; VACULOVIČOVÁ, M.; KOPEL, P.; HUBÁLEK, J.; KIZEK, R.; ADAM, V.
RIV year
2013
Released
1. 9. 2013
Publisher
LANDES BIOSCIENCE
Location
1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
ISBN
1933-6896
Periodical
PRION
Year of study
7
Number
5
State
United States of America
Pages from
349
Pages to
358
Pages count
10
BibTex
@article{BUT104157, author="Pavlína {Adam} and Iva {Blažková} and Jana {Pekárková} and Jana {Drbohlavová} and Markéta {Vaculovičová} and Pavel {Kopel} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}", title="Quantum dots and prion proteins Is this a new challenge for neurodegenerative diseases imaging?", journal="PRION", year="2013", volume="7", number="5", pages="349--358", doi="10.4161/pri.26524", issn="1933-6896" }