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PŘICHYSTALOVÁ, H. ALMONASY, N. ABDEL-LATTIF, A. ABDEL-RAHMAN, R. FOUDA, M. VOJTOVÁ, L. KOBĚRA, L. SPOTZ, Z. BURGERT, L. JANČÁŘ, J.
Original Title
Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives
Type
journal article in Web of Science
Language
English
Original Abstract
The present work aims to the development of innovative new derivatives of chitosan that can be used for medical applications. This innovation is based on the synthesis and characterization of chitosan-g-aminoanthracene derivatives. Thus, N-(anthracen-9-yl)-4,6- dichloro-[1,3,5]-triazin-2-amine (AT) reacted with chitosan by the following steps: At first, cyanuric chloride reacted with 9-aminoanthracene to obtain N-(anthracen-9-yl)-4,6-dichloro- 40 [1,3,5]-triazin-2-amine (AT), then the AT reacted with chitosan to obtain (CH -g-AT). The final product of CH-g-AT was separated, purified and re-crystallized by dioxan. The structure of the prepared chitosan derivatives was confirmed by FTIR-ATR, solid-NMR, TGA, X-RD, and DSC. The new chitosan derivatives showed fluorescence spectra in liquid and in solid state as well. CH-g-AT showed also high antibacterial activity against gram-negative species (Escherichia coli).
Keywords
chitosan, antibacterial activity, fluorescent derivatives
Authors
PŘICHYSTALOVÁ, H.; ALMONASY, N.; ABDEL-LATTIF, A.; ABDEL-RAHMAN, R.; FOUDA, M.; VOJTOVÁ, L.; KOBĚRA, L.; SPOTZ, Z.; BURGERT, L.; JANČÁŘ, J.
RIV year
2014
Released
1. 4. 2014
ISBN
0141-8130
Periodical
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Year of study
65
Number
1
State
Kingdom of the Netherlands
Pages from
234
Pages to
240
Pages count
580
BibTex
@article{BUT105081, author="Hana {Přichystalová} and Numan {Almonasy} and Abdelmohsen Moustafa {Abdellatif} and Rasha M. {Abdel-Rahman} and Moustafa M.D. {Fouda} and Lucy {Vojtová} and Libor {Koběra} and Zdeněk {Spotz} and Ladislav {Burgert} and Josef {Jančář}", title="Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives", journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES", year="2014", volume="65", number="1", pages="234--240", doi="10.1016/j.ijbiomac.2014.01.050", issn="0141-8130" }