Publication detail

The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters

BARTOŠ, M. JIŘÍK, R. KRATOCHVÍLA, J. STANDARA, M. STARČUK, Z. TAXT, T.

Original Title

The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters

Type

journal article in Web of Science

Language

English

Original Abstract

The present trend in dynamic contrast-Enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, the distributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated perfusion parameters can be described by the covariance matrix for signal-to-noise ratio higher than ~ 20 dB. The application of the new analysis model on a real DCE-MRI data set is also presented.

Keywords

Dynamic contrast-enhanced MRI (DCE-MRI); perfusion; parameter estimation; bolus arrival time

Key words in English

Dynamic contrast-enhanced MRI (DCE-MRI); perfusion; parameter estimation; bolus arrival time

Authors

BARTOŠ, M.; JIŘÍK, R.; KRATOCHVÍLA, J.; STANDARA, M.; STARČUK, Z.; TAXT, T.

RIV year

2014

Released

1. 6. 2014

Publisher

Elsevier

ISBN

0730-725X

Periodical

MAGNETIC RESONANCE IMAGING

Year of study

32

Number

5

State

United States of America

Pages from

505

Pages to

513

Pages count

9

BibTex

@article{BUT105502,
  author="Michal {Bartoš} and Radovan {Jiřík} and Jiří {Kratochvíla} and Michal {Standara} and Zenon {Starčuk} and Torfinn {Taxt}",
  title="The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters",
  journal="MAGNETIC RESONANCE IMAGING",
  year="2014",
  volume="32",
  number="5",
  pages="505--513",
  doi="10.1016/j.mri.2014.02.003",
  issn="0730-725X"
}