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GUMULEC, J. BALVAN, J. SZTALMACHOVÁ, M. RAUDENSKÁ, M. TANHÄUSEROVÁ, V. KNOPFOVÁ, L. POLANSKÁ, H. HUDCOVÁ, K. RUTTKAY-NEDECKÝ, B. BABULA, P. ADAM, V. KIZEK, R. STIBOROVÁ, M. MASAŘÍK, M.
Original Title
Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle
Type
journal article in Web of Science
Language
English
Original Abstract
Differences in the antioxidant system, apoptotic mechanism and in cell cycle between prostatic cell lines could partially elucidate the development of cisplatin resistance. The aim of this study was to identify the most characteristic parameter for a particular cell line and/or a particular cisplatin treatment using a general regression model and to assess whether it is possible to use measured parameters as markers of cisplatin resistance. This study integrates the results of viability, antioxidant, flow cytometric and quantitative PCR assays in order to characterize the resistance of prostate cancer to cisplatin.
Keywords
prostate cancer, cell cycle, resistance, cisplatin, oxidative stress,
Authors
GUMULEC, J.; BALVAN, J.; SZTALMACHOVÁ, M.; RAUDENSKÁ, M.; TANHÄUSEROVÁ, V.; KNOPFOVÁ, L.; POLANSKÁ, H.; HUDCOVÁ, K.; RUTTKAY-NEDECKÝ, B.; BABULA, P.; ADAM, V.; KIZEK, R.; STIBOROVÁ, M.; MASAŘÍK, M.
RIV year
2014
Released
8. 4. 2014
ISBN
1019-6439
Periodical
INTERNATIONAL JOURNAL OF ONCOLOGY
Year of study
44
Number
3
State
Hellenic Republic
Pages from
923
Pages to
933
Pages count
11
BibTex
@article{BUT105768, author="Jaromír {Gumulec} and Jan {Balvan} and Markéta {Sztalmachová} and Martina {Raudenská} and Veronika {Tanhäuserová} and Lucia {Knopfová} and Hana {Polanská} and Kristýna {Hudcová} and Branislav {Ruttkay-Nedecký} and Petr {Babula} and Vojtěch {Adam} and René {Kizek} and Marie {Stiborová} and Michal {Masařík}", title="Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle", journal="INTERNATIONAL JOURNAL OF ONCOLOGY", year="2014", volume="44", number="3", pages="923--933", doi="10.3892/ijo.2013.2223", issn="1019-6439" }