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EL-SHAMY, I. ABDEL-LATTIF, A. FOUDA, M. ALMONASY, N. AL-DEYAB, S. EL-HASHASH, M.
Original Title
Selenium containing heterocyclic: Synthesis, antimicrobial of some new selenazole Substituted phthalazin-ones
Type
journal article - other
Language
English
Original Abstract
The principal purpose of the present study is to synthesize and investigate the antimicrobial and antifungal activities of new 1, 3-selenazole derivatives having phthalazin-1(2H)-one moieties. A multi-step reaction route was developed to synthesize a several of targeted derivatives starting from 4-alkyl/aryl-phthalazin-1(2H)-one and 2-chloro-N-phenylacetamide. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis. The antimicrobial and antifungal activities of all derivatives against four species of bacteria and two species of fungi were investigated. The antimicrobial and antifungal activity was determined in the extracts using disk diffusion method. Amoxicillin and Ketoconazole were used as standard drugs for the bacteria and fungi, respectively.
Keywords
Selenium, phthalazin-1(2H)-one, antimicrobial activity
Authors
EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; ALMONASY, N.; AL-DEYAB, S.; EL-HASHASH, M.
RIV year
2013
Released
18. 10. 2013
ISBN
1097-8135
Periodical
Life Science Journal
Year of study
10
Number
4
State
People's Republic of China
Pages from
799
Pages to
809
Pages count
11
BibTex
@article{BUT106135, author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Numan {Almonasy} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}", title="Selenium containing heterocyclic: Synthesis, antimicrobial of some new selenazole Substituted phthalazin-ones", journal="Life Science Journal", year="2013", volume="10", number="4", pages="799--809", issn="1097-8135" }