Publication detail

Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water

KOMÍNKOVÁ, M. HEGER, Z. ZÍTKA, O. KYNICKÝ, J. POHANKA, M. BEKLOVÁ, M. ADAM, V. KIZEK, R.

Original Title

Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water

Type

journal article in Web of Science

Language

English

Original Abstract

Platinum-based cytostatics, such as cisplatin, carboplatin or oxaliplatin are widely used agents in the treatment of various types of tumors. Large amounts of these drugs are excreted through the urine of patients into wastewaters in unmetabolised forms. This phenomenon leads to increased amounts of platinum ions in the water environment. The impacts of these pollutants on the water ecosystem are not sufficiently investigated as well as their content in water sources. In order to facilitate the detection of various types of platinum, we have developed a new, rapid, screening flow injection analysis method with electrochemical detection (FIA-ED). Our method, based on monitoring of the changes in electrochemical behavior of analytes, maintained by various pH buffers (Britton-Robinson and phosphate buffer) and potential changes (1,000, 1,100 and 1,200 mV) offers rapid and cheap selective determination of platinum-based cytostatics and platinum chlorides, which can also be present as contaminants in water environments.

Keywords

platinum-based cytostatics; platinum chlorides; flow injection analysis with electrochemical detection; hydrodynamic voltammograms

Authors

KOMÍNKOVÁ, M.; HEGER, Z.; ZÍTKA, O.; KYNICKÝ, J.; POHANKA, M.; BEKLOVÁ, M.; ADAM, V.; KIZEK, R.

RIV year

2014

Released

4. 2. 2014

Publisher

MDPI

ISBN

1660-4601

Periodical

International Journal of Environmental Research and Public Health

Year of study

11

Number

2

State

Swiss Confederation

Pages from

1715

Pages to

1724

Pages count

10

URL

http://www.mdpi.com/1660-4601/11/2/1715

Full text in the Digital Library

http://hdl.handle.net/11012/63718

BibTex

@article{BUT106906,
  author="Markéta {Komínková} and Zbyněk {Heger} and Ondřej {Zítka} and Jindřich {Kynický} and Miroslav {Pohanka} and Miroslava {Beklová} and Vojtěch {Adam} and René {Kizek}",
  title="Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water",
  journal="International Journal of Environmental Research and Public Health",
  year="2014",
  volume="11",
  number="2",
  pages="1715--1724",
  doi="10.3390/ijerph110201715",
  issn="1660-4601",
  url="http://www.mdpi.com/1660-4601/11/2/1715"
}