Publication detail

Prokaryotic DNA Signal Downsampling for Fast Whole Genome Comparison

SEDLÁŘ, K. ŠKUTKOVÁ, H. VÍTEK, M. PROVAZNÍK, I.

Original Title

Prokaryotic DNA Signal Downsampling for Fast Whole Genome Comparison

Type

journal article in Scopus

Language

English

Original Abstract

Classification of prokaryotes is mainly based on molecular data, since next-generation sequencing platforms provide fast and effective way to capture prokaryotes characteristics. However, two different bacterial strains of the same genus can differ in the specific parts of their genomes due to copious amounts of repetitive and transposable parts. Thus, finding an ideal segment of genome for comparison is difficult. Conventional character-based methods rely on multiple sequence alignment, rendering them extremely computationally demanding. Only small parts of genomes can be compared in reasonable time. In this paper, we present a novel algorithm based on the conversion of the whole genome sequences to cumulative phase signals. Dyadic wavelet transform (DWT) is used for lossy compression of phase signals by eliminating redundant frequency bands. Signal classification is then performed as cluster analysis using Euclidean metrics where sequence alignment is replaced by dynamic time warping (DTW).

Keywords

prokaryotes, genomic signal, cumulated phase, compression, classification, dwt, dtw

Authors

SEDLÁŘ, K.; ŠKUTKOVÁ, H.; VÍTEK, M.; PROVAZNÍK, I.

RIV year

2014

Released

1. 6. 2014

Publisher

Springer International Publishing

Location

Německo

ISBN

2194-5357

Periodical

Advances in Intelligent Systems and Computing

Year of study

283

Number

6

State

Swiss Confederation

Pages from

373

Pages to

383

Pages count

11

BibTex

@article{BUT107893,
  author="Karel {Sedlář} and Helena {Vítková} and Martin {Vítek} and Valentine {Provazník}",
  title="Prokaryotic DNA Signal Downsampling for Fast Whole Genome Comparison",
  journal="Advances in Intelligent Systems and Computing",
  year="2014",
  volume="283",
  number="6",
  pages="373--383",
  doi="10.1007/978-3-319-06593-9\{_}33",
  issn="2194-5357"
}