Publication detail

Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

TMEJOVÁ, K. KREJČOVÁ, L. HYNEK, D. ADAM, V. BABULA, P. TRNKOVÁ, L. STIBOROVÁ, M. ECKSCHLAGER, T. KIZEK, R.

Original Title

Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

Type

journal article in Web of Science

Language

English

Original Abstract

Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.

Keywords

Adsorptive transfer stripping technique, DNA, differential pulse voltammetry, ellipticine, hetero-nucleotides, intercalation, square wave voltammetry, cancer, therapy

Authors

TMEJOVÁ, K.; KREJČOVÁ, L.; HYNEK, D.; ADAM, V.; BABULA, P.; TRNKOVÁ, L.; STIBOROVÁ, M.; ECKSCHLAGER, T.; KIZEK, R.

RIV year

2014

Released

1. 2. 2014

ISBN

1871-5206

Periodical

Anti-Cancer Agents in Medicinal Chemistry

Year of study

14

Number

2

State

United Arab Emirates

Pages from

331

Pages to

340

Pages count

10

BibTex

@article{BUT110907,
  author="Kateřina {Tmejová} and Ludmila {Krejčová} and David {Hynek} and Vojtěch {Adam} and Petr {Babula} and Libuše {Trnková} and Marie {Stiborová} and Tomáš {Eckschlager} and René {Kizek}",
  title="Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides",
  journal="Anti-Cancer Agents in Medicinal Chemistry",
  year="2014",
  volume="14",
  number="2",
  pages="331--340",
  issn="1871-5206"
}