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KENŠOVÁ, R. HYNEK, D. KYNICKÝ, J. NOVOTNÁ, M. ECKSCHLAGER, T. ADAM, V. HUBÁLEK, J. KIZEK, R.
Original Title
Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry
Type
journal article in Web of Science
Language
English
Original Abstract
The aim of this study was to investigate the interaction between lead ions and ethylenediaminetetraacetic acid (EDTA) in plasma. EDTA is widely used in medicine as anticoagulant agent. Understanding of the influence of EDTA on the electrochemical lead ions determination is very suitable for the determination of lead ions at patients with increased metals levels in body fluids. Further, the changes of metal ions levels (Zn, Cd, Pb and Cu) were monitored in the blood plasma of child patients treated for various oncological diseases. Electrochemical method differential pulse voltammetry with fully automated system and atomic absorption spectrometry was used for determination of the metal ions. It was found an increased amount of metal ions in the blood plasma of patients suffering from cancer disease in comparison with physiological values in healthy people. In these patients there was also found that they have higher levels of metallothionein and the ratio of GSH/GSSG was reduced. These results suggest that tumour diseases cause important changes in the level of ions.
Keywords
Metals; Electrochemical Analysis; Plasma; EDTA; Interaction; Oncological Diseases
Authors
KENŠOVÁ, R.; HYNEK, D.; KYNICKÝ, J.; NOVOTNÁ, M.; ECKSCHLAGER, T.; ADAM, V.; HUBÁLEK, J.; KIZEK, R.
RIV year
2014
Released
1. 8. 2014
Publisher
ESG
ISBN
1452-3981
Periodical
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
Year of study
9
Number
8
State
Republic of Serbia
Pages from
4675
Pages to
4691
Pages count
17
URL
http://www.electrochemsci.org/papers/vol9/90804675.pdf
Full text in the Digital Library
http://hdl.handle.net/11012/201446
BibTex
@article{BUT111179, author="Renáta {Kenšová} and David {Hynek} and Jindřich {Kynický} and Marie {Novotná} and Tomáš {Eckschlager} and Vojtěch {Adam} and Jaromír {Hubálek} and René {Kizek}", title="Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry", journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE", year="2014", volume="9", number="8", pages="4675--4691", issn="1452-3981", url="http://www.electrochemsci.org/papers/vol9/90804675.pdf" }