Publication detail

MALDI-TOF MS as evolving cancer diagnostic tool: A review

MERLOS RODRIGO, M. ZÍTKA, O. KŘÍŽKOVÁ, S. MOULICK, A. ADAM, V. KIZEK, R.

Original Title

MALDI-TOF MS as evolving cancer diagnostic tool: A review

Type

journal article in Web of Science

Language

English

Original Abstract

Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013

Keywords

Mass spectrometry, Imaging, Tissue profiling, Cancer biomarkers, MALDI-TOF

Authors

MERLOS RODRIGO, M.; ZÍTKA, O.; KŘÍŽKOVÁ, S.; MOULICK, A.; ADAM, V.; KIZEK, R.

RIV year

2014

Released

1. 7. 2014

ISBN

0731-7085

Periodical

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Year of study

95

Number

1

State

Kingdom of the Netherlands

Pages from

245

Pages to

255

Pages count

11

BibTex

@article{BUT111182,
  author="Miguel Ángel {Merlos Rodrigo} and Ondřej {Zítka} and Soňa {Křížková} and Amitava {Moulick} and Vojtěch {Adam} and René {Kizek}",
  title="MALDI-TOF MS as evolving cancer diagnostic tool: A review",
  journal="JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS",
  year="2014",
  volume="95",
  number="1",
  pages="245--255",
  doi="10.1016/j.jpba.2014.03.007",
  issn="0731-7085"
}