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HOLUBOVÁ, M. AXMANOVÁ, M. GUMULEC, J. RAUDENSKÁ, M. SZTALMACHOVÁ, M. BABULA, P. ADAM, V. KIZEK, R. MASAŘÍK, M.
Original Title
KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer
Type
journal article in Web of Science
Language
English
Original Abstract
Zinc(II) ions are important components of many proteins and are involved in numerous cellular processes such as apoptosis or drug resistance. Prostate cancer has a unique relationship with zinc(II) ions. However, the relationship was examined only in short-term zinc(II) treatments. Therefore, the aim of this study was to create zinc-resistant prostatic cell lines at various stages of the disease (22Rv1 and PC-3) and a normal prostate epithelium (PNT1A) using a long-term zinc exposure.
Keywords
CITRATE METABOLISM; EPITHELIAL-CELLS; CARCINOMA-CELLS; DNA-DAMAGE; T-ANTIGEN; EXPRESSION; METALLOTHIONEIN; TRANSPORTER; APOPTOSIS; GENES
Authors
HOLUBOVÁ, M.; AXMANOVÁ, M.; GUMULEC, J.; RAUDENSKÁ, M.; SZTALMACHOVÁ, M.; BABULA, P.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.
RIV year
2014
Released
1. 7. 2014
ISBN
1756-5901
Periodical
METALLOMICS
Year of study
6
Number
7
State
United Kingdom of Great Britain and Northern Ireland
Pages from
1240
Pages to
1253
Pages count
14
BibTex
@article{BUT111196, author="Monika {Kratochvílová} and Martina {Axmanová} and Jaromír {Gumulec} and Martina {Raudenská} and Markéta {Svobodová} and Petr {Babula} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}", title="KRAS NF-jB is involved in the development of zinc resistance and reduced curability in prostate cancer", journal="METALLOMICS", year="2014", volume="6", number="7", pages="1240--1253", doi="10.1039/c4mt00065j", issn="1756-5901" }