Publication detail

Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one

EL-SHAMY, I. BAKEER, H. AL-SHAMRANI, K. ABDEL-LATTIF, A. AL-SHEHRI, M.

Original Title

Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one

Type

journal article in Scopus

Language

English

Original Abstract

A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis.

Keywords

N-glycosyl; phthalazinone; antimicrobial activity, Benzamidazole

Authors

EL-SHAMY, I.; BAKEER, H.; AL-SHAMRANI, K.; ABDEL-LATTIF, A.; AL-SHEHRI, M.

RIV year

2014

Released

1. 4. 2014

ISBN

1097-8135

Periodical

Life Science Journal

Year of study

11

Number

4

State

People's Republic of China

Pages from

94

Pages to

99

Pages count

6

BibTex

@article{BUT112296,
  author="Ibrahim E. {El-Shamy} and Hadeer M. {Bakeer} and Khalid M. {Al-Shamrani} and Abdelmohsen Moustafa {Abdellatif} and Mohammed M. {Al-Shehri}",
  title="Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one",
  journal="Life Science Journal",
  year="2014",
  volume="11",
  number="4",
  pages="94--99",
  issn="1097-8135"
}