Publication detail

Clinical significance of head and neck squamous cell cancer biomarkers

POLANSKÁ, H. RAUDENSKÁ, M. GUMULEC, J. SZTALMACHOVÁ, M. ADAM, V. KIZEK, R. MASAŘÍK, M.

Original Title

Clinical significance of head and neck squamous cell cancer biomarkers

Type

journal article in Web of Science

Language

English

Original Abstract

Head and neck tumors belong among the six leading causes of cancer death worldwide. The predominant type of head and neck tumors consists of squamous cell carcinomas (HNSCC). Early detection of primary tumor and relapse is a key factor for enhancing the survival rate of HNSCC patients, because high rates of cases are recognized at advanced stages. Accordingly, biomarkers suitable for the early detection of HNSCC are sorely needed to improve patient outcomes. HNSCC evolve through a multistep process by the accumulation of genetic and phenotypic changes. Searching for specific biomarkers capable of characterizing each degree is therefore really essential. In this review, genomic and gene expression alterations of HNSCC are summarized and associated with HPV status, clinicopathological conditions, and patient history from the perspective of potential biomarker utilization. The emphasis is placed on non-invasive markers detectable from saliva and blood and clinically relevant studies are mentioned in particular. These include analyses of tumorous tissues, saliva, and blood from patients with histologically defined tumors; cell culture- and other in vitro-based studies with no clinical correlations are rather excluded.

Keywords

Head and neck cancer Tumor markers Cancer Prognosis Papillomavirus miRNA Saliva

Authors

POLANSKÁ, H.; RAUDENSKÁ, M.; GUMULEC, J.; SZTALMACHOVÁ, M.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

RIV year

2014

Released

1. 3. 2014

ISBN

1368-8375

Periodical

ORAL ONCOLOGY

Year of study

50

Number

3

State

United Kingdom of Great Britain and Northern Ireland

Pages from

168

Pages to

177

Pages count

10

BibTex

@article{BUT112438,
  author="Hana {Polanská} and Martina {Raudenská} and Jaromír {Gumulec} and Markéta {Svobodová} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="Clinical significance of head and neck squamous cell cancer biomarkers",
  journal="ORAL ONCOLOGY",
  year="2014",
  volume="50",
  number="3",
  pages="168--177",
  doi="10.1016/j.oraloncology.2013.12.008",
  issn="1368-8375"
}