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LÍZAL, F. BĚLKA, M. ADAM, J. JEDELSKÝ, J. JÍCHA, M.
Original Title
A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography
Type
journal article in Web of Science
Language
English
Original Abstract
This article introduces a method based on positron emission tomography, which allows acquisition of detailed experimental data on local aerosol deposition in a realistic model of human lungs. The method utilizes the Condensation Monodisperse Aerosol Generator modified for a safe production of radioactive aerosol particles and a special measuring rig. The scanning of the model is performed on a positron emission tomography–computed tomography scanner. The evaluation of aerosol deposition is based on a volume radioactivity analysis in a specialized, yet publicly available software. The reliability of the method was tested and its first results are discussed in the article. The measurements performed using the presented method can serve for validation of numerical simulations, since the presented lung model digital geometry is available.
Keywords
positro emission tomography, aerosol, aerosol deposition, targeted drug delivery
Authors
LÍZAL, F.; BĚLKA, M.; ADAM, J.; JEDELSKÝ, J.; JÍCHA, M.
RIV year
2015
Released
1. 10. 2015
Publisher
SAGE Publications
Location
London, UK
ISBN
0954-4119
Periodical
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
Year of study
229
Number
10
State
United Kingdom of Great Britain and Northern Ireland
Pages from
750
Pages to
757
Pages count
8
BibTex
@article{BUT117312, author="František {Lízal} and Miloslav {Bělka} and Jan {Adam} and Jan {Jedelský} and Miroslav {Jícha}", title="A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography", journal="PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE", year="2015", volume="229", number="10", pages="750--757", doi="10.1177/0954411915600005", issn="0954-4119" }