Publication detail

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

VRÁNA, O. NOVOHRADSKÝ, V. MEDŘÍKOVÁ, Z. BURDÍKOVÁ, J. STUCHLÍKOVÁ, O. KAŠPÁRKOVÁ, J. BRABEC, V.

Original Title

Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic

Type

journal article in Web of Science

Language

English

Original Abstract

Anticancer therapy by platinum complexes, based on nanocarrier-based delivery, may offer a new approach to improve the efficacy and tolerability of the platinum family of anticancer drugs. The original rules for the design of new anticancer platinum drugs were affected by the fact that, although cisplatin (cis-[PtCl2(NH3)2) was an anticancer drug, its isomer transplatin was not cytotoxic. For the first time, it is demonstrated that simple encapsulation of an inactive platinum compound in phospholipid bilayers transforms it into an efficient cytotoxic agent. Notably, the encapsulation of transplatin makes it possible to overcome the resistence mechanisms operating in cancer cells treated with cisplatin and prevents inactivation of transplatin in the extracellular environment. It is also shown that transplatin delivered to the cells in nanocapsules, in contrast to free (nonencapsulated) complex, forms cytotoxic cross-links on DNA.

Keywords

Cancer; DNA; liposomes; phospholipids; platinum

Authors

VRÁNA, O.; NOVOHRADSKÝ, V.; MEDŘÍKOVÁ, Z.; BURDÍKOVÁ, J.; STUCHLÍKOVÁ, O.; KAŠPÁRKOVÁ, J.; BRABEC, V.

Released

20. 1. 2016

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

Location

Weinheim

ISBN

0947-6539

Periodical

CHEMISTRY-A EUROPEAN JOURNAL

Year of study

22

Number

1

State

Federal Republic of Germany

Pages from

2728

Pages to

2735

Pages count

8

BibTex

@article{BUT122264,
  author="Oldřich {Vrána} and Vojtěch {Novohradský} and Zdenka {Medříková} and Jana {Burdíková} and Olga {Stuchlíková} and Jana {Kašpárková} and Viktor {Brabec}",
  title="Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic",
  journal="CHEMISTRY-A EUROPEAN JOURNAL",
  year="2016",
  volume="22",
  number="1",
  pages="2728--2735",
  doi="10.1002/chem.201504671",
  issn="0947-6539"
}