Publication detail

Microarray analysis of metallothioneins in human diseases-A review

KŘÍŽKOVÁ, S. KEPINSKA, M. EMRI, G. MERLOS RODRIGO, M. TMEJOVÁ, K. NERUDOVÁ, D. KÍZEK, R. ADAM, V.

Original Title

Microarray analysis of metallothioneins in human diseases-A review

Type

journal article in Web of Science

Language

English

Original Abstract

Metallothioneins (MTs), low molecular mass cysteine-rich proteins, which are able to bind up to 20 monovalent and up to 7 divalent heavy metal ions are widely studied due to their functions in detoxification of metals, scavenging free radicals and cells protection against the oxidative stress. It was found that the loss of the protective effects of MT leads to an escalation of pathogenic processes and carcinogenesis. The most extensive area is MTs expression for oncological applications, where the information about gene patterns is helpful for the identification biological function, resistance to drugs and creating the correct chemotherapy. In other medical applications the effect of oxidative stress to cell lines exposed to heavy metals and hydrogen peroxide is studied as well as influence of drugs and cytokines on MTs expression and MTs expression in the adipose tissue. The precise detection of low metallothionein concentrations and its isoforms is necessary to understand the connection between quantity and isoforms of MTs to size, localization and type of cancer. This information is necessary for well-timed therapy and increase the chance to survival. Microarray chips appear as good possibility for finding all information about expression of MTs genes and isoforms not only in cancer, but also in other diseases, especially diabetes, obesity, cardiovascular diseases, ageing, osteoporosis, psychiatric disorders and as the effects of toxic drugs and pollutants, which is discussed in this review.

Keywords

Drug; Gene expression; Metallothionein; Microarray; Resistance; Tumour diseases

Authors

KŘÍŽKOVÁ, S.; KEPINSKA, M.; EMRI, G.; MERLOS RODRIGO, M.; TMEJOVÁ, K.; NERUDOVÁ, D.; KÍZEK, R.; ADAM, V.

Released

5. 1. 2016

ISBN

0731-7085

Periodical

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Year of study

117

Number

1

State

Kingdom of the Netherlands

Pages from

464

Pages to

473

Pages count

9

BibTex

@article{BUT123338,
  author="Soňa {Křížková} and Marta {Kepinska} and Gabriela {Emri} and Miguel Ángel {Merlos Rodrigo} and Kateřina {Tmejová} and Danuše {Nerudová} and René {Kizek} and Vojtěch {Adam}",
  title="Microarray analysis of metallothioneins in human diseases-A review",
  journal="JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS",
  year="2016",
  volume="117",
  number="1",
  pages="464--473",
  doi="10.1016/j.jpba.2015.09.031",
  issn="0731-7085"
}