Publication detail

The Functional Organization of Human Epileptic Hippocampus

KLIMEŠ, P. HALÁMEK, J. JURÁK, P.

Original Title

The Functional Organization of Human Epileptic Hippocampus

Type

journal article in Web of Science

Language

English

Original Abstract

The function and connectivity of human brain is disrupted in epilepsy. We previously reported that the region of epileptic brain generating focal seizures, i.e. the seizure onset zone (SOZ), is functionally isolated from surrounding brain regions in focal neocortical epilepsy. The modulatory effect of behavioral state on the spatial and spectral scales over which the reduced functional connectivity occurs, however, is unclear. Here we use simultaneous sleep staging from scalp EEG with intracranial EEG recordings from medial temporal lobe to investigate how behavioral state modulates the spatial and spectral scales of local field potential synchrony in focal epileptic hippocampus. The local field spectral power and linear correlation between adjacent electrodes provide measures of neuronal population synchrony at different spatial scales, ~1 and 10 mm, respectively. Our results show increased connectivity inside the SOZ and low connectivity between electrodes in SOZ and outside the SOZ. During slow wave sleep, we observed decreased connectivity for ripple and fast ripple frequency bands within the SOZ at the 10 mm spatial scale, while the local synchrony remained high at the 1 mm spatial scale. Further study of these phenomena may prove useful for SOZ localization and help understand seizure generation, and the functional deficits seen in epileptic eloquent cortex.

Keywords

intracranial EEG, epilepsy, seizure onset zone, behavioral state, connectivity

Authors

KLIMEŠ, P.; HALÁMEK, J.; JURÁK, P.

Released

30. 3. 2016

Publisher

Journal of Neurophysiology

ISBN

0022-3077

Periodical

JOURNAL OF NEUROPHYSIOLOGY

Year of study

4

Number

115

State

United States of America

Pages from

1

Pages to

10

Pages count

10

URL

http://jn.physiology.org/content/early/2016/03/25/jn.00089.2016.long

BibTex

@article{BUT124102,
  author="Petr {Klimeš} and Josef {Halámek} and Pavel {Jurák}",
  title="The Functional Organization of Human Epileptic Hippocampus",
  journal="JOURNAL OF NEUROPHYSIOLOGY",
  year="2016",
  volume="4",
  number="115",
  pages="1--10",
  doi="10.1152/jn.00089.2016",
  issn="0022-3077",
  url="http://jn.physiology.org/content/early/2016/03/25/jn.00089.2016.long"
}