Publication detail

Cell type specificity of neurovascular coupling in cerebral cortex

UHLÍŘOVÁ, H. KILIÇ, K. TIAN, P. THUNEMANN, M. DESJARDINS, M. SAISAN, P. SAKADŽIC, S. NESS, T. MATEO, C. CHENG, Q. WELDY, K. RAZOUX, F. VANDENBERGHE, M. CREMONESI, J. FERRI, C. NIZAR, K. SRIDHAR, V. STEED, T. ABASHIN, M. FAINMAN, Y. MASLIAH, E. DJUROVIC, S. ANDREASSEN, O. SILVA, G. BOAS, D. KLEINFELD, D. BUXTON, R. EINEVOLL, G. DALE, A. DEVOR, A.

Original Title

Cell type specificity of neurovascular coupling in cerebral cortex

Type

journal article in Web of Science

Language

English

Original Abstract

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

Keywords

cerebrovascular regulation, 2-photon imaging

Authors

UHLÍŘOVÁ, H.; KILIÇ, K.; TIAN, P.; THUNEMANN, M.; DESJARDINS, M.; SAISAN, P.; SAKADŽIC, S.; NESS, T.; MATEO, C.; CHENG, Q.; WELDY, K.; RAZOUX, F.; VANDENBERGHE, M.; CREMONESI, J.; FERRI, C.; NIZAR, K.; SRIDHAR, V.; STEED, T.; ABASHIN, M.; FAINMAN, Y.; MASLIAH, E.; DJUROVIC, S.; ANDREASSEN, O.; SILVA, G.; BOAS, D.; KLEINFELD, D.; BUXTON, R.; EINEVOLL, G.; DALE, A.; DEVOR, A.

Released

31. 5. 2016

Publisher

eLife Sciences Publications

ISBN

2050-084X

Periodical

eLife

Year of study

5

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

23

Pages count

23

URL

https://elifesciences.org/content/5/e14315

Full text in the Digital Library

http://hdl.handle.net/11012/204286

BibTex

@article{BUT126695,
  author="Hana {Uhlířová} and Kıvılcım {Kılıç} and Pfeifang {Tian} and Martin {Thunemann} and Michele {Desjardins} and Payam A. {Saisan} and Sava {Sakadžic} and Torbjørn V {Ness} and Celine {Mateo} and Qun {Cheng} and Kimberly L. {Weldy} and Florence {Razoux} and Matthieu {Vandenberghe} and Jonathan A {Cremonesi} and Christopher GL {Ferri} and Krystal {Nizar} and Vishnu B. {Sridhar} and Tyler C. {Steed} and Maxim {Abashin} and Yeshaiahu {Fainman} and Eliezer {Masliah} and Srdjan {Djurovic} and Ola A {Andreassen} and Gabriel A. {Silva} and David A. {Boas} and David {Kleinfeld} and Richard B {Buxton} and Gaute T. {Einevoll} and Anders M. {Dale} and Anna {Devor}",
  title="Cell type specificity of neurovascular coupling in cerebral cortex",
  journal="eLife",
  year="2016",
  volume="5",
  number="1",
  pages="1--23",
  doi="10.7554/elife.14315",
  issn="2050-084X",
  url="https://elifesciences.org/content/5/e14315"
}