Publication detail

Characterization of the Colloidal Properties of a Microbubble Contrast Agent

PILGROVÁ, T. ŘÍKOVSKÁ, K. PEKAŘ, M.

Original Title

Characterization of the Colloidal Properties of a Microbubble Contrast Agent

Type

conference paper

Language

English

Original Abstract

Microbubbles are used as contrast agents in combination with ultrasound mostly for cardiovascular imaging and the assessment of perfusion of various organs and tumors. These systems are currently proposed for drug delivery applications. In the development process of a new contrast agent or drug delivery system is necessary to know colloidal properties of the system such as size distribution of microbubbles, phase stability of the system or progress of microbubble formation process. The aim of our study was to evaluate mentioned properties of contrast agent SonoVue® and analogous phospholipid systems. Systems were studied using spectroscopic methods including UV-VIS spectroscopy and dynamic light scattering technique. Microbubble formation process was investigated by means of maximum bubble pressure tensiometry. It was found that surface activity as well as composition of the system is significant for microbubble formation process. Dynamic light scattering method shows that size of SonoVue® microbubble is about 1000 nm but size distribution of the analogous system is larger which implies that preparation method influence final properties of the studied system

Keywords

microbubble, contrast agent, colloidal properties, size distribution, tensiometry

Authors

PILGROVÁ, T.; ŘÍKOVSKÁ, K.; PEKAŘ, M.

RIV year

2015

Released

3. 12. 2015

Publisher

Vysoké učení technické v Brně, Fakulta chemická

Location

Purkyňova 464/118, 612 00 Brno

ISBN

978-80-214-5290-9

Book

Studentská odborná konference Chemie je život 2015 Sborník příspěvků

Edition number

první

Pages from

289

Pages to

294

Pages count

6

URL

http://www.fch.vutbr.cz/media/sok/sbornik_prispevku_2015.pdf

BibTex

@inproceedings{BUT127432,
  author="Tereza {Pilgrová} and Klára {Říkovská} and Miloslav {Pekař}",
  title="Characterization of the Colloidal Properties of a Microbubble Contrast Agent",
  booktitle="Studentská odborná konference Chemie je život 2015
Sborník příspěvků",
  year="2015",
  number="první",
  pages="289--294",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  address="Purkyňova 464/118, 612 00 Brno",
  isbn="978-80-214-5290-9",
  url="http://www.fch.vutbr.cz/media/sok/sbornik_prispevku_2015.pdf"
}