Publication detail

Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode

NGUYEN, H. RICHTERA, L. MOULICK, A. XHAXHIU, K. KUDR, J. CERNEI, N. POLANSKÁ, H. HEGER, Z. MASAŘÍK, M. KOPEL, P. STIBOROVÁ, M. ECKSCHLAGER, T. ADAM, V. KIZEK, R.

Original Title

Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode

Type

journal article in Web of Science

Language

English

Original Abstract

In this study, enhancement of the electrochemical signals of etoposide (ETO) measured by differential pulse voltammetry (DPV) by modifying a glassy carbon electrode (GCE) with carbon quantum dots (CQDs) is demonstrated. In comparison with a bare GCE, the modified GCE exhibited a higher sensitivity towards electrochemical detection of ETO. The lowest limit of detection was observed to be 5 nM ETO. Furthermore, scanning electron microscopy (SEM), fluorescence microscopy (FM), and electrochemical impedance spectroscopy (EIS) were employed for the further study of the working electrode surface after the modification with CQDs. Finally, the GCE modified with CQDs under optimized conditions was used to analyse real samples of ETO in the prostate cancer cell line PC3. After different incubation times (1, 3, 6, 9, 12, 18 and 24 h), these samples were then prepared prior to electrochemical detection by the GCE modified with CQDs. High performance liquid chromatography with an electrochemical detection method was employed to verify the results from the GCE modified with CQDs.

Keywords

Etoposide (ETO), Differential Pulse Voltammetry (DPV), Glassy Carbon Electrode (GCE), Carbon Quantum Dots (CQDs)

Authors

NGUYEN, H.; RICHTERA, L.; MOULICK, A.; XHAXHIU, K.; KUDR, J.; CERNEI, N.; POLANSKÁ, H.; HEGER, Z.; MASAŘÍK, M.; KOPEL, P.; STIBOROVÁ, M.; ECKSCHLAGER, T.; ADAM, V.; KIZEK, R.

Released

1. 5. 2016

ISBN

0003-2654

Periodical

ANALYST

Year of study

141

Number

9

State

United Kingdom of Great Britain and Northern Ireland

Pages from

2665

Pages to

2675

Pages count

11

BibTex

@article{BUT128556,
  author="Hoai Viet {Nguyen} and Lukáš {Richtera} and Amitava {Moulick} and Kledi {Xhaxhiu} and Jiří {Kudr} and Natalia Vladimirovna {Cernei} and Hana {Polanská} and Zbyněk {Heger} and Michal {Masařík} and Pavel {Kopel} and Marie {Stiborová} and Tomáš {Eckschlager} and Vojtěch {Adam} and René {Kizek}",
  title="Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode",
  journal="ANALYST",
  year="2016",
  volume="141",
  number="9",
  pages="2665--2675",
  doi="10.1039/c5an02476e",
  issn="0003-2654"
}