Publication detail

The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

JANOUŠEK, O. RONZHINA, M. HEJČ, J. STRAČINA, T. OLEJNÍČKOVÁ, V. NOVÁKOVÁ, M. PROVAZNÍK, I. KOLÁŘOVÁ, J.

Original Title

The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart

Type

conference paper

Language

English

Original Abstract

Presence of heart rate variability (HRV) in isolated hearts is widely recognized; however, its mechanisms are still subject of debate. One of the possible explanations is that mechanoreceptors in cardiac tissue affect HRV. In order to evaluate possible dependence of HRV on heart mechanoreceptors activated during left ventricle filling, the HRV parameters in two perfusion modes of isolated heart were compared: Langendorff and working heart mode. Ten New Zealand rabbit isolated hearts were perfused (Krebs-Henseleit, 37 degrees C, 85 mmHg) in Langendorff mode and consecutively in working heart mode (8 cmH(2)O preload, 60 cmH(2)O afterload). A total of 27 HRV parameters in time, frequency, geometric, and non-linear domain were computed. No significant differences (Wilcoxon signed rank test, p < 0.05) were found among all studied HRV parameters between Langendorff and working heart mode. The study confirms the presence of heart rate fluctuation in isolated hearts in both Langendorff and working heart modes. Results of statistical analysis show that heart rate fluctuation is irrespective to mechanical stimulation of heart during atrium and ventricle filling.

Keywords

heart rate variability; cardiac filling; rabbit isolated heart

Authors

JANOUŠEK, O.; RONZHINA, M.; HEJČ, J.; STRAČINA, T.; OLEJNÍČKOVÁ, V.; NOVÁKOVÁ, M.; PROVAZNÍK, I.; KOLÁŘOVÁ, J.

Released

30. 9. 2016

Publisher

Computing in Cardiology, 2016.

Location

Vancouver, CA

ISBN

978-1-5090-0684-7

Book

Computing in Cardiology 2016

Edition

43

Edition number

1

ISBN

0276-6574

Periodical

Computers in Cardiology

State

United States of America

Pages from

501

Pages to

504

Pages count

4

URL

https://ieeexplore.ieee.org/document/7868789

BibTex

@inproceedings{BUT128842,
  author="Oto {Janoušek} and Marina {Filipenská} and Jakub {Hejč} and Tibor {Stračina} and Veronika {Olejníčková} and Marie {Nováková} and Valentine {Provazník} and Jana {Kolářová}",
  title="The Effect of Cardiac Filling on Heart Rate Variability in Rabbit Isolated Heart",
  booktitle="Computing in Cardiology 2016",
  year="2016",
  series="43",
  journal="Computers in Cardiology",
  number="1",
  pages="501--504",
  publisher="Computing in Cardiology, 2016.",
  address="Vancouver, CA",
  doi="10.22489/CinC.2016.143-254",
  isbn="978-1-5090-0684-7",
  issn="0276-6574",
  url="https://ieeexplore.ieee.org/document/7868789"
}