Publication detail

Effects of ionizing radiation on nucleic acids and transcription factors

KUDR, J. HEGER, Z.

Original Title

Effects of ionizing radiation on nucleic acids and transcription factors

Type

journal article - other

Language

English

Original Abstract

Nucleic acids and transcription factors represent biopolymers of vital importance in all living organisms. Their main aim is coding, transcription and translation of genetic information and responsible for complex regulation of these fundamental physiological processes. However ionizing radiation is ubiquitous and played crucial role in evolution probably, long-term exposition to low doses possess broad spectrum of negative effects on health. Interaction of ionizing radiation with nucleic acids and transcription factors result in damage and nonphysiological activation of these polymers. Effects of ionizing radiation on nucleic acids, different kinds of DNA damage and reparation mechanisms are broadly discussed in this work together with effects on important proteins – transcription factors.

Keywords

cancer; DNA damage; phosphorylation; mutation; signaling pathway

Authors

KUDR, J.; HEGER, Z.

Released

1. 1. 2016

ISBN

2336-3940

Periodical

Journal of Metallomics and Nanotechnologies

Year of study

2

Number

4

State

Czech Republic

Pages from

22

Pages to

29

Pages count

8

BibTex

@article{BUT131485,
  author="Jiří {Kudr} and Zbyněk {Heger}",
  title="Effects of ionizing radiation on nucleic acids and transcription factors",
  journal="Journal of Metallomics and Nanotechnologies",
  year="2016",
  volume="2",
  number="4",
  pages="22--29",
  issn="2336-3940"
}