Publication detail

Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

SUOMI, V. JAROŠ, J. TREEBY, B. CLEVELAND, R.

Original Title

Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney

Type

conference paper

Language

English

Original Abstract

Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney. The combined effect of inhomogeneous attenuation and sound-speed was found to result in an 11.0 dB drop in spatial peak-temporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0.1 dB. Focal point shifting due to refraction effects resulted in -1.3, 2.6 and 1.3 mm displacements in x-, y-and z-directions respectively. Furthermore, focal point splitting into several smaller subvolumes was observed. The total volume of the secondary focal points was approximately 46% of the largest primary focal point. This could potentially lead to undesired heating outside the target location and longer therapy times.

Keywords

HIFU, k-Wave, ultrasound, kidney, 3D nonlinear simulation

Authors

SUOMI, V.; JAROŠ, J.; TREEBY, B.; CLEVELAND, R.

Released

13. 10. 2016

Publisher

Institute of Electrical and Electronics Engineers

Location

Orlando

ISBN

978-1-4577-0220-4

Book

38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)

Edition

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Pages from

5648

Pages to

5651

Pages count

4

URL

http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615

BibTex

@inproceedings{BUT132591,
  author="Visa {Suomi} and Jiří {Jaroš} and Bradley {Treeby} and Robin {Cleveland}",
  title="Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney",
  booktitle="38th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)",
  year="2016",
  series="Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
  pages="5648--5651",
  publisher="Institute of Electrical and Electronics Engineers",
  address="Orlando",
  doi="10.1109/EMBC.2016.7592008",
  isbn="978-1-4577-0220-4",
  url="http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615"
}

Documents

2016-Suomi-EMBC-Kidney-annotated.pdf