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KOVÁŘ, D. HUBÁLEK, J. FOHLEROVÁ, Z. MALÁ, A. KALINA, M. JIŘÍK, R. STARČUK, Z. SKLÁDAL, P. HLAVÁČEK, A.
Original Title
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
Type
journal article in Web of Science
Language
English
Original Abstract
Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities and ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising -contrast probe.
Keywords
magnetic nanoparticles, MRI imaging
Authors
KOVÁŘ, D.; HUBÁLEK, J.; FOHLEROVÁ, Z.; MALÁ, A.; KALINA, M.; JIŘÍK, R.; STARČUK, Z.; SKLÁDAL, P.; HLAVÁČEK, A.
Released
23. 2. 2017
Publisher
Hindawi Publishing Corporation
ISBN
1687-4110
Periodical
JOURNAL OF NANOMATERIALS
Year of study
2017
Number
1
State
United States of America
Pages from
Pages to
8
Pages count
URL
http://dx.doi.org/10.1155/2017/7859289
Full text in the Digital Library
http://hdl.handle.net/11012/68359
BibTex
@article{BUT134091, author="David {Kovář} and Jaromír {Hubálek} and Zdenka {Fohlerová} and Aneta {Malá} and Michal {Kalina} and Radovan {Jiřík} and Antonín {Hlaváček} and Ondřej {Slabý} and Petr {Skládal} and Zdeněk {Farka} and Jitka {Mlčochová} and Zenon {Starčuk jr.}", title="Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging", journal="JOURNAL OF NANOMATERIALS", year="2017", volume="2017", number="1", pages="1--8", doi="10.1155/2017/7859289", issn="1687-4110", url="http://dx.doi.org/10.1155/2017/7859289" }