Publication detail

Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation

ROBERTSON, J. COX, B. JAROŠ, J. TREEBY, B.

Original Title

Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation

Type

journal article in Web of Science

Language

English

Original Abstract

Non-invasive, focal neurostimulation with ultrasound is a potentially powerful neuroscientific tool that requires effective transcranial focusing of ultrasound to develop. Time-reversal (TR) focusing using numerical simulations of transcranial ultrasound propagation can correct for the effect of the skull, but relies on accurate simulations. Here, focusing requirements for ultrasonic neurostimulation are established through a review of previously employed ultrasonic parameters, and consideration of deep brain targets. The specific limitations of finite-difference time domain (FDTD) and k-space corrected pseudospectral time domain (PSTD) schemes are tested numerically to establish the spatial points per wavelength and temporal points per period needed to achieve the desired accuracy while minimizing the computational burden. These criteria are confirmed through convergence testing of a fully simulated TR protocol using a virtual skull. The k-space PSTD scheme performed as well as, or better than, the widely used FDTD scheme across all individual error tests and in the convergence of large scale models, recommending it for use in simulated TR. Staircasing was shown to be the most serious source of error. Convergence testing indicated that higher sampling is required to achieve fine control of the pressure amplitude at the target than is needed for accurate spatial targeting.

Keywords

Transcranial neurostimulation, focused ultrasound, numerical simulation

Authors

ROBERTSON, J.; COX, B.; JAROŠ, J.; TREEBY, B.

Released

13. 3. 2017

ISBN

1520-8524

Periodical

Journal of the Acoustical Society of America

Year of study

141

Number

3

State

United States of America

Pages from

1726

Pages to

1738

Pages count

13

URL

http://asa.scitation.org/doi/10.1121/1.4976339

Full text in the Digital Library

http://hdl.handle.net/11012/68367

BibTex

@article{BUT134713,
  author="James {Robertson} and Ben {Cox} and Jiří {Jaroš} and Bradley {Treeby}",
  title="Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation",
  journal="Journal of the Acoustical Society of America",
  year="2017",
  volume="141",
  number="3",
  pages="1726--1738",
  doi="10.1121/1.4976339",
  issn="1520-8524",
  url="http://asa.scitation.org/doi/10.1121/1.4976339"
}

Documents

2017-Robertson-JASA-annotated.pdf