Publication detail

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

KAUCKÁ, M. ZIKMUND, T. TESAŘOVÁ, M. GYLLBORG, D. HELLANDER, A. JAROŠ, J. KAISER, J. PETERSEN, J. SZAROWSKA, B. NEWTON, P.T. DYACHUK, V. LI, L. QIAN, H. JOHANSSON, A-S. MISHINA, Y. CURRIE, J. TANAKA, E.M. ERICKSON, A. DUDLEY, A. BRISMAR, H. SOUTHAM, P. COEN, E. CHEN, M. WEINSTEIN, L.S. HAMPL, A. ARENAS, E. CHAGIN, A.S. FRIED, K. ADAMEYKO, I.

Original Title

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage

Type

journal article in Web of Science

Language

English

Original Abstract

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Keywords

cell dynamics, cartilaginous elements, growth, cartilage

Authors

KAUCKÁ, M.; ZIKMUND, T.; TESAŘOVÁ, M.; GYLLBORG, D.; HELLANDER, A.; JAROŠ, J.; KAISER, J.; PETERSEN, J.; SZAROWSKA, B.; NEWTON, P.T.; DYACHUK, V.; LI, L.; QIAN, H.; JOHANSSON, A-S.; MISHINA, Y.; CURRIE, J.; TANAKA, E.M.; ERICKSON, A.; DUDLEY, A.; BRISMAR, H.; SOUTHAM, P.; COEN, E.; CHEN, M.; WEINSTEIN, L.S.; HAMPL, A.; ARENAS, E.; CHAGIN, A.S.; FRIED, K.; ADAMEYKO, I.

Released

17. 4. 2017

Publisher

eLife Sciences Publications

ISBN

2050-084X

Periodical

eLife

Year of study

6

Number

4

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

82

Pages count

82

URL

https://elifesciences.org/content/6/e25902

Full text in the Digital Library

http://hdl.handle.net/11012/65749

BibTex

@article{BUT134851,
  author="KAUCKÁ, M. and ZIKMUND, T. and TESAŘOVÁ, M. and GYLLBORG, D. and HELLANDER, A. and JAROŠ, J. and KAISER, J. and PETERSEN, J. and SZAROWSKA, B. and NEWTON, P.T. and DYACHUK, V. and LI, L. and QIAN, H. and JOHANSSON, A-S. and MISHINA, Y. and CURRIE, J. and TANAKA, E.M. and ERICKSON, A. and DUDLEY, A. and BRISMAR, H. and SOUTHAM, P. and COEN, E. and CHEN, M. and WEINSTEIN, L.S. and HAMPL, A. and ARENAS, E. and CHAGIN, A.S. and FRIED, K. and ADAMEYKO, I.",
  title="Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage",
  journal="eLife",
  year="2017",
  volume="6",
  number="4",
  pages="1--82",
  doi="10.7554/eLife.25902",
  issn="2050-084X",
  url="https://elifesciences.org/content/6/e25902"
}