Publication detail

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

GANDALOVIČOVÁ, A. RÖSEL, D. FERNANDES, M. VESELÝ, P. HENEBERG, P. ČERMÁK, V. PETRUŽELKA, L. KUMAR, S. SANZ-MORENO, V. BRÁBEK, J.

Original Title

Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

Type

journal article in Web of Science

Language

English

Original Abstract

In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ‘migrastatics’ for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers.

Keywords

solid cancer; metastasis; invasion; treatment; contractility; migrastatics

Authors

GANDALOVIČOVÁ, A.; RÖSEL, D.; FERNANDES, M.; VESELÝ, P.; HENEBERG, P.; ČERMÁK, V.; PETRUŽELKA, L.; KUMAR, S.; SANZ-MORENO, V.; BRÁBEK, J.

Released

1. 6. 2017

Publisher

Elsevier

ISBN

2405-8033

Periodical

Trends in Cancer

Year of study

3

Number

6

State

United States of America

Pages from

391

Pages to

406

Pages count

16

URL

https://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7

Full text in the Digital Library

http://hdl.handle.net/11012/84149

BibTex

@article{BUT136334,
  author="Aneta {Gandalovičová} and Daniel {Rösel} and Michael {Fernandes} and Pavel {Veselý} and Petr {Henenberg} and Vladimír {Čermák} and Luboš {Petruželka} and Sunil {Kumar} and Victoria {Sanz-Moreno} and Jan {Brábek}",
  title="Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges",
  journal="Trends in Cancer",
  year="2017",
  volume="3",
  number="6",
  pages="391--406",
  doi="10.1016/j.trecan.2017.04.008",
  issn="2405-8033",
  url="https://www.cell.com/trends/cancer/abstract/S2405-8033(17)30085-7"
}