Publication detail

A new method for macrolide antibiotics determination in wastewaters from three different wastewater treatment plants

LANDOVÁ, P. VÁVROVÁ, M.

Original Title

A new method for macrolide antibiotics determination in wastewaters from three different wastewater treatment plants

Type

journal article in Web of Science

Language

English

Original Abstract

An effective and practical method for the determination of macrolide antibiotics azithromycin, clarithromycin, erythromycin and roxithromycin in wastewater samples has been developed. The analytical method combines solid phase extraction followed by a chromatographic separation by hydrophilic interaction liquid chromatography (HILIC) coupled with an ion trap mass spectrometer utilizing the electrospray ionization technique. Detection of positively charged ions was performed in full scan mode from 500 to 900 m/z. The method detection limits and method quantification limits obtained were in the range of 2.03 – 7.59 ng L-1 and 6.08 – 23.84 ng L-1, respectively. Recoveries of solid phase extraction were obtained using SupelTM-Select HLB cartridges ranging from 85.76 % to 92.54 %. All target antibiotics were detected in 100 % of the collected raw influent samples with concentrations varying from 15 ng L-1 to 1849 ng L-1. Azithromycin, clarithromycin and erythromycin were also detected in 100 % of the treated water samples and roxithromycin was present in 96 % of the samples. The highest determined concentration in the treated water samples was 1404 ng L-1 of azithromycin. Based on the determined macrolide concentrations, removal efficiencies of individual wastewater treatment plants were calculated to range from 13 % to 100 %.

Keywords

high-performance liquid chromatography; macrolide antibiotics; mass spectrometry; solid phase extraction; wastewater.

Authors

LANDOVÁ, P.; VÁVROVÁ, M.

Released

23. 6. 2017

ISBN

1337-978X

Periodical

Acta Chemica Slovaca

Year of study

10

Number

1

State

Slovak Republic

Pages from

47

Pages to

53

Pages count

7

URL

http://www.acs.chtf.stuba.sk/papers/acs_0270.pdf

BibTex

@article{BUT137180,
  author="Pavlína {Landová} and Milada {Vávrová}",
  title="A new method for macrolide antibiotics determination in wastewaters from three different wastewater treatment plants",
  journal="Acta Chemica Slovaca",
  year="2017",
  volume="10",
  number="1",
  pages="47--53",
  doi="10.1515/acs-2017-2018",
  issn="1337-978X",
  url="http://www.acs.chtf.stuba.sk/papers/acs_0270.pdf"
}