Publication detail

Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement

PAŠTĚKA, R. FORJAN, M.

Original Title

Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement

Type

abstract

Language

English

Original Abstract

Aerosols are a ubiquitous part of the surrounding environment. Airborne particles may be produced by intention, as several spray-based cosmetics, but are not intended to be inhaled. The number of deposited particles in the lung tissue can only be estimated using mathematical models or simplified organ models. However, the question of actually deposited particles remains. The presented active lung simulator, i-Lung, has been designed to enable active inand exhalation and live measurement of environmental aerosols with a particle size distribution of 0.2 μm - 40 μm, representing respirable and inhalable aerosols. The i-Lung simulates an active spontaneously breathing human lung by changing the pressure within the housing of the different applicable lung equivalents as Latex bags or porcine lungs. An extracorporeal perfusion circuit, based on human lung transplantation techniques, is developed alongside and is supposed to nourish porcine lungs, taken from the slaughtering process.

Keywords

Aerosol measurements, mechanical lung simulator, respiratory system model

Authors

PAŠTĚKA, R.; FORJAN, M.

Released

24. 8. 2017

Publisher

ALTEX

Location

Kuesnacht, Switzerland

ISBN

2194-0479

Periodical

ALTEX proceedings

Year of study

6

Number

1

State

Swiss Confederation

Pages from

47

Pages to

48

Pages count

1

URL

http://www.altex.ch/altex-proceedings/wc-10-seattle

BibTex

@misc{BUT138970,
  author="PAŠTĚKA, R. and FORJAN, M.",
  title="Evaluation of an Active Lung Simulator for Aerosol Inhalation Test Replacement",
  booktitle="Alternatives and Animal Use in the Life Sciences: 3Rs in Action, Seattle, Washington, August 2017",
  year="2017",
  journal="ALTEX proceedings",
  volume="6",
  number="1",
  pages="47--48",
  publisher="ALTEX",
  address="Kuesnacht, Switzerland",
  issn="2194-0479",
  url="http://www.altex.ch/altex-proceedings/wc-10-seattle",
  note="abstract"
}